Protein Information

Cytoscape View


UniProt AC / UniProt ID P29084 / T2EB_HUMAN
Protein Name Transcription initiation factor IIE subunit beta
Gene Name Name: GTF2E2
Synonyms:TF2E2;
Organism Homo sapiens (Human)

PRO ID PR:P29084
DAG View
PRO Name transcription initiation factor IIE subunit beta (human)
Definition A transcription initiation factor IIE subunit beta that is encoded in the genome of human.
Short Label hGTF2E2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29084 (GTF2E2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S4 Phosphorylation PhosphoSitePlus
S18 Phosphorylation HPRD   PhosphoSitePlus 18212344
T19 Phosphorylation PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S29 Phosphorylation HPRD 20068231
S35 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus   UniProt 23186163
K86 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K238 Methylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 I4 Biomuta DOID:363 / uterine cancer [ tcga ]
T87 A87 Biomuta DOID:363 / uterine cancer [ tcga ]
T121 I121 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
K129 R129 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K183 E183 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K198 N198 Biomuta DOID:363 / uterine cancer [ cosmic ]
S227 F227 Biomuta DOID:363 / uterine cancer [ tcga ]
K282 N282 Biomuta DOID:10534 / stomach cancer [ tcga ]