Protein Information

Cytoscape View


UniProt AC / UniProt ID P29083 / T2EA_HUMAN
Protein Name General transcription factor IIE subunit 1
Gene Name Name: GTF2E1
Synonyms:TF2E1;
Organism Homo sapiens (Human)

PRO ID PR:P29083
DAG View
PRO Name general transcription factor IIE subunit 1 (human)
Definition A general transcription factor IIE subunit 1 that is encoded in the genome of human.
Short Label hGTF2E1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29083 (GTF2E1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
T8 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K19 Methylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus   UniProt 19608861
K67 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
T98 Phosphorylation HPRD 20068231
Y188 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
S268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K272 Ubiquitination PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K15 T15 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y91 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y92 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K272 R272 Biomuta DOID:1909 / melanoma [ cosmic ]
S333 F333 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S334 C334 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]