iPTMnet Report for P29033 (GJB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29033 / CXB2_HUMAN
Protein Name Gap junction beta-2 protein
Gene Name Name: GJB2
Organism Homo sapiens (Human)

PRO ID PR:P29033
DAG View
PRO Name gap junction beta-2 protein (human)
Definition A gap junction beta-2 protein that is encoded in the genome of human.
Short Label hGJB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29033 (GJB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K15 Acetylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K122 Sumoylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
K221 Methylation PhosphoSitePlus
K223 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R75 L75 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K105 * Biomuta DOID:1612 / breast cancer [ cosmic ]