iPTMnet Report for P28908 (TNFRSF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28908 / TNR8_HUMAN
Protein Name Tumor necrosis factor receptor superfamily member 8 precursor
Gene Name Name: TNFRSF8
Synonyms:CD30;
Organism Homo sapiens (Human)

PRO ID PR:P28908
DAG View
PRO Name tumor necrosis factor receptor superfamily member 8 (human)
Definition A tumor necrosis factor receptor superfamily member 8 that is encoded in the genome of human.
Short Label hTNFRSF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28908 (TNFRSF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N101 N-Glycosylation GlyGen 24190977
C131 Methylation IEDB 31844290
N165 N-Glycosylation GlyGen 24190977
S206 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T209 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N276 N-Glycosylation GlyGen 24190977
N295 N-Glycosylation GlyGen 24190977
K419 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus   UniProt 23186163
S443 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
T445 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
T454 Phosphorylation PhosphoSitePlus
C472 Methylation IEDB 31844290
Y479 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation IEDB   PhosphoSitePlus 35494241
Y560 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S206 T206 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T209 M209 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T445 M445 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S452 L452 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y479 C479 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S496 F496 Biomuta DOID:4159 / skin cancer [ cosmic ]