iPTMnet Report for P28799 (GRN)
Protein Information
| UniProt AC / UniProt ID | P28799 / GRN_HUMAN |
| Protein Name | Progranulin precursor |
| Gene Name | Name: GRN |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P28799 |
| PRO Name | progranulin (human) |
| Definition | A progranulin that is encoded in the genome of human. |
| Short Label | hGRN |
| Category | organism-gene |
DAG ViewP28799 (GRN) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S81 | Phosphorylation | P05771 (PRKCB) | score3 | PhosphoSitePlus RLIMS-P | 26005049 | |
| N118 | N-Glycosylation | score3 | GlyGen UniProt | 20188224 | ||
| C178 | Methylation | score1 | IEDB | 31844290 | ||
| T180 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T182 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| T182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S205 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N236 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
| C253 | Methylation | score1 | IEDB | 31844290 | ||
| N265 | N-Glycosylation | score4 | GlyGen UniProt | 23090970, 20188224, 19159218, ... | ||
| K273 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C335 | Methylation | score1 | IEDB | 31844290 | ||
| N368 | N-Glycosylation | score3 | GlyGen UniProt | 20188224 | ||
| S435 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K497 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N530 | N-Glycosylation | score4 | GlyGen UniProt | 23090970, 29741879, 24190977, ... | ||
| T532 | O-Glycosylation | score1 | GlyGen | 33214551, 30237853, 30397120, ... | ||
| N537 | N-Glycosylation | score1 | GlyGen | 24190977 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P28799 (GRN) | S81 | P28799 (GRN) | unknown | eFIP | 26005049 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S205 | L205 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S435 | F435 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| N530 | S530 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| N530 | I530 | Biomuta | DOID:1725 / peritoneum cancer [ cosmic ] | |
| N530 | K530 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
