iPTMnet Report for P28749 (RBL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28749 / RBL1_HUMAN
Protein Name Retinoblastoma-like protein 1
Gene Name Name: RBL1
Organism Homo sapiens (Human)

PRO ID PR:P28749
DAG View
PRO Name retinoblastoma-like protein 1 (human)
Definition A retinoblastoma-like protein 1 that is encoded in the genome of human.
Short Label hRBL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28749 (RBL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T88 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
T332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610, 23186163
T337 Phosphorylation PhosphoSitePlus
T340 Phosphorylation phospho.ELM   PhosphoSitePlus 12006580
S368 Phosphorylation PhosphoSitePlus
T369 Phosphorylation P11802 (CDK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12006580, 11884610, 23186163, ...22094256
T372 Phosphorylation PhosphoSitePlus
T385 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610, 23186163, ...19690332
S389 Phosphorylation PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
S615 Phosphorylation phospho.ELM   PhosphoSitePlus 12006580
S640 Phosphorylation P11802 (CDK4) , P24941 (CDK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 22094256, 11884610, 23186163, ...17495531, 12006580
S643 Phosphorylation PhosphoSitePlus
Y648 Phosphorylation PhosphoSitePlus
S650 Phosphorylation P24941 (CDK2) , P11802 (CDK4) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12006580, 17495531, 27567532
T652 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S749 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 23186163, 19690332
S757 Phosphorylation PhosphoSitePlus
S762 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610, 23186163, ...19690332
T769 Phosphorylation PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
T915 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
Y938 Phosphorylation PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
S964 Phosphorylation P11802 (CDK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22094256, 11884610, 12006580
S975 Phosphorylation P11802 (CDK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 22094256, 11884610, 12006580, ...10069453, 27567532
S980 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
Y986 Phosphorylation PhosphoSitePlus
S988 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610, 23186163
S994 Phosphorylation PhosphoSitePlus
T997 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610
S1000 Phosphorylation PhosphoSitePlus
Y1004 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 11884610
S1011 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12006580, 23186163
Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation HPRD 18491316
S103 Phosphorylation HPRD 18491316
T332 Phosphorylation HPRD 12006580, 19664994
T340 Phosphorylation HPRD 12006580
T369 Phosphorylation P11802 (CDK4) HPRD   PRO 12006580, 11884610, 19664994, ...19664995
T385 Phosphorylation HPRD 12006580
S615 Phosphorylation HPRD 12006580
S640 Phosphorylation HPRD   PRO 12006580, 11884610
S650 Phosphorylation P11802 (CDK4) HPRD 12006580
S749 Phosphorylation HPRD 12006580
S762 Phosphorylation HPRD 12006580
S964 Phosphorylation P11802 (CDK4) HPRD   PRO 12006580, 11884610
S975 Phosphorylation HPRD   PRO 12006580, 11884610
S984 Phosphorylation HPRD 19413330
Y986 Phosphorylation HPRD 19413330
S988 Phosphorylation HPRD 19413330, 12006580
S994 Phosphorylation HPRD 19413330
T997 Phosphorylation HPRD 12006580
S1009 Phosphorylation HPRD 12006580
S1041 Phosphorylation HPRD 12006580
Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation HPRD 18491316
S103 Phosphorylation HPRD 18491316
T332 Phosphorylation HPRD 12006580, 19664994
T340 Phosphorylation HPRD 12006580
T369 Phosphorylation P11802 (CDK4) HPRD 12006580, 19664994, 19664995
T385 Phosphorylation HPRD 12006580
S615 Phosphorylation HPRD 12006580
S640 Phosphorylation HPRD 12006580
S650 Phosphorylation P11802 (CDK4) HPRD 12006580
S749 Phosphorylation HPRD 12006580
S762 Phosphorylation HPRD 12006580
S964 Phosphorylation P11802 (CDK4) HPRD 12006580
S975 Phosphorylation HPRD 12006580
S984 Phosphorylation HPRD 19413330
Y986 Phosphorylation HPRD 19413330
S988 Phosphorylation HPRD 19413330, 12006580
S994 Phosphorylation HPRD 19413330
T997 Phosphorylation HPRD 12006580
S1009 Phosphorylation HPRD 12006580


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049024 (hRBL1/Phos:1) pT369,pS640,pS964,pS975 PRO
PR:000036470 (hRBL1/iso:1/Phos:1) pT369,pS640,pS964,pS975 PRO 11884610


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036470 (hRBL1/iso:1/Phos:1) Interaction PRO 11884610
PR:P28749-1 (hRBL1/iso:1) Interaction PRO 11884610


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S389 L389 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S615 C615 Biomuta DOID:1612 / breast cancer [ cosmic ]
S615 F615 Biomuta DOID:1612 / breast cancer [ cosmic ]
S650 A650 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S650 F650 Biomuta DOID:363 / uterine cancer [ icgc ]
S757 L757 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S757 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S975 L975 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S988 F988 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1000 R1000 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]