Protein Information

Cytoscape View


UniProt AC / UniProt ID P28715 / ERCC5_HUMAN
Protein Name DNA excision repair protein ERCC-5
Gene Name Name: ERCC5
Synonyms:ERCM2,XPG,XPGC;
Organism Homo sapiens (Human)

PRO ID PR:P28715
DAG View
PRO Name DNA repair protein complementing XP-G cells (human)
Definition A DNA repair protein complementing XP-G cells that is encoded in the genome of human.
Short Label hERCC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28715 (ERCC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Acetylation PhosphoSitePlus   UniProt 19608861
K8 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S156 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S157 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
K172 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S287 O-Glycosylation GlyGen 29351928
Y289 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S310 O-Glycosylation GlyGen 29351928
K313 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
T338 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S341 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
T344 Phosphorylation PhosphoSitePlus
S355 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983
S357 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983
S363 Phosphorylation PhosphoSitePlus
S382 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983, ...18220336
S389 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S423 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S424 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S428 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
K433 Ubiquitination PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T523 Phosphorylation PhosphoSitePlus
S526 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 18220336
S558 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S559 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S562 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S563 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 17081983
T567 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
K972 Ubiquitination PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
T1020 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
K1071 Methylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
S1129 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
K1139 Acetylation PhosphoSitePlus
T1145 Phosphorylation PhosphoSitePlus
S1147 Phosphorylation PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S100 Phosphorylation HPRD 20068231
S156 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S157 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T338 Phosphorylation HPRD 18669648, 15302935, 20068231
S341 Phosphorylation HPRD 20166139, 18669648, 15302935, ...20068231
S355 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S356 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S357 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S363 Phosphorylation HPRD 20068231
S382 Phosphorylation HPRD 18669648, 20068231
S384 Phosphorylation HPRD 19413330, 18691976, 18491316, ...20058876, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 18767875, 19415658, 20068231
S423 Phosphorylation HPRD 18669648
S424 Phosphorylation HPRD 18669648
S428 Phosphorylation HPRD 18669648, 15302935
S526 Phosphorylation HPRD 17322306, 18767875, 19664994, ...19664995, 20068231
S558 Phosphorylation HPRD 18669648, 17081983
S559 Phosphorylation HPRD 19651622, 18669648, 17081983
S562 Phosphorylation HPRD 19413330, 17322306, 18767875, ...18452278, 19651622, 18669648, 20068231
S563 Phosphorylation HPRD 19413330, 17322306, 18767875, ...18452278, 19651622, 18669648, 20068231
T567 Phosphorylation HPRD 19651622
S724 Phosphorylation HPRD 17081983, 18452278
T738 Phosphorylation HPRD 20068231
T920 Phosphorylation HPRD 20068231
T924 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S100 N100 Biomuta DOID:363 / uterine cancer [ tcga ]
S156 N156 Biomuta DOID:363 / uterine cancer [ tcga ]
T344 S344 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
K402 E402 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S428 I428 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S558 P558 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S558 Y558 Biomuta DOID:363 / uterine cancer [ tcga ]
S559 A559 Biomuta DOID:10534 / stomach cancer [ tcga ]
S559 F559 Biomuta DOID:1324 / lung cancer [ tcga ]
S662 I662 Biomuta DOID:1612 / breast cancer [ tcga ]
S678 L678 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1012 N1012 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1032 I1032 Biomuta DOID:3571 / liver cancer [ icgc ]
S1069 R1069 Biomuta DOID:4362 / cervical cancer [ cosmic, tcga ]
S1149 I1149 Biomuta DOID:1612 / breast cancer [ cosmic ]