iPTMnet Report for P28347 (TEAD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28347 / TEAD1_HUMAN
Protein Name Transcriptional enhancer factor TEF-1
Gene Name Name: TEAD1
Synonyms:TCF13,TEF1;
Organism Homo sapiens (Human)

PRO ID PR:P28347
DAG View
PRO Name transcriptional enhancer factor TEF-1 (human)
Definition A transcriptional enhancer factor TEF-1 that is encoded in the genome of human.
Short Label hTEAD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28347 (TEAD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692, 20068231
S4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
S20 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
C53 Methylation IEDB 31844290
K57 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K83 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K101 Methylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   RLIMS-P 10931933
K108 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S126 O-Glycosylation GlyGen 33214551, 34725712, 31492838, ...35289036, 30059200
S127 O-Glycosylation GlyGen 33214551, 34725712, 31492838, ...35289036, 30059200
S132 O-Glycosylation GlyGen 33214551, 34725712, 31492838, ...35289036, 30059200
K173 Sumoylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K95 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 C4 Biomuta DOID:1324 / lung cancer [ cosmic ]
C53 Y53 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S61 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K83 Q83 Biomuta DOID:1324 / lung cancer [ cosmic ]
K83 N83 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K101 N101 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S126 F126 Biomuta [ cosmic ]
S127 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S132 L132 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K265 N265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]