iPTMnet Report for P28329 (CHAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28329 / CLAT_HUMAN
Protein Name Choline O-acetyltransferase
Gene Name Name: CHAT
Organism Homo sapiens (Human)

PRO ID PR:P28329
DAG View
PRO Name choline O-acetyltransferase (human)
Definition A choline O-acetyltransferase that is encoded in the genome of human.
Short Label hCHAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28329 (CHAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T366 O-Glycosylation GlyGen 29237092
S372 O-Glycosylation GlyGen 29237092
T373 O-Glycosylation GlyGen 29237092
T373 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , P05129 (PRKCG) Signor 12486117, 15381704
S377 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
S464 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , Q02156 (PRKCE) , P17252 (PRKCA) Signor 15381704
S465 Phosphorylation P05129 (PRKCG) , P17252 (PRKCA) , P05771 (PRKCB) , Q02156 (PRKCE) Signor 15381704
S473 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
S558 Phosphorylation Q05513 (PRKCZ) , P05771 (PRKCB) , P17252 (PRKCA) , Q05655 (PRKCD) , Q02156 (PRKCE) , P05129 (PRKCG) Signor 15381704
T574 Phosphorylation Q9UQM7 (CAMK2A) Signor 12486117
S594 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) , Q05655 (PRKCD) , Q02156 (PRKCE) , P05129 (PRKCG) , Q05513 (PRKCZ) Signor 15381704
Site PTM Type PTM Enzyme Score Source PMID
T373 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD 15381704
S464 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , P17252 (PRKCA) HPRD 15381704
S465 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) , P05129 (PRKCG) HPRD 15381704
S475 Phosphorylation HPRD 19664994
S558 Phosphorylation P05771 (PRKCB) , P05129 (PRKCG) , Q02156 (PRKCE) , Q05655 (PRKCD) , P17252 (PRKCA) , Q05513 (PRKCZ) HPRD 12486117, 15381704, 10861222
T574 Phosphorylation Q13555 (CAMK2G) , Q9UQM7 (CAMK2A) HPRD 12486117, 10861222
S594 Phosphorylation Q05513 (PRKCZ) , P05771 (PRKCB) , P17252 (PRKCA) , Q05655 (PRKCD) , Q02156 (PRKCE) , P05129 (PRKCG) HPRD 15381704
Site PTM Type PTM Enzyme Score Source PMID
T255 Phosphorylation P05129 (PRKCG) , P05771-2 (PRKCB) , P17252 (PRKCA) HPRD   PhosphoSitePlus 15381704
S346 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , P05129 (PRKCG) HPRD   PhosphoSitePlus 15381704
S347 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , P05129 (PRKCG) HPRD   PhosphoSitePlus 15381704
S357 Phosphorylation HPRD 19664994
S440 Phosphorylation P05129 (PRKCG) , Q05655 (PRKCD) , P05771 (PRKCB) , Q05513 (PRKCZ) , Q02156 (PRKCE) , P17252 (PRKCA) HPRD   PhosphoSitePlus 12486117, 15381704, 10861222
T456 Phosphorylation Q13555 (CAMK2G) , Q9UQM7 (CAMK2A) HPRD   PhosphoSitePlus 12486117, 10861222
S476 Phosphorylation P05129 (PRKCG) , P05771 (PRKCB) , Q05513 (PRKCZ) , Q05655 (PRKCD) , P17252 (PRKCA) , Q02156 (PRKCE) HPRD   PhosphoSitePlus 15381704


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K7 R7 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K16 T16 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T123 N123 Biomuta DOID:363 / uterine cancer [ icgc ]
S237 N237 Biomuta DOID:4159 / skin cancer [ cosmic ]
S357 G357 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T366 M366 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S377 L377 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T456 I456 Biomuta DOID:1324 / lung cancer [ cosmic ]
S473 Y473 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S475 G475 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T574 I574 Biomuta DOID:1324 / lung cancer [ cosmic ]