Protein Information

Cytoscape View


UniProt AC / UniProt ID P28223 / 5HT2A_HUMAN
Protein Name 5-hydroxytryptamine receptor 2A
Gene Name Name: HTR2A
Synonyms:HTR2;
Organism Homo sapiens (Human)

PRO ID PR:P28223
DAG View
PRO Name 5-hydroxytryptamine receptor 2A (human)
Definition A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human.
Short Label hHTR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28223 (HTR2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S280 Phosphorylation PhosphoSitePlus   UniProt 24637012
S287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S280 Y280 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S288 P288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S288 Y288 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S288 C288 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S298 L298 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y419 * Biomuta DOID:3571 / liver cancer [ icgc ]