iPTMnet Report for P28070 (PSMB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P28070 / PSB4_HUMAN
Protein Name Proteasome subunit beta type-4 precursor
Gene Name Name: PSMB4
Synonyms:PROS26;
Organism Homo sapiens (Human)

PRO ID PR:P28070
DAG View
PRO Name proteasome subunit beta type-4 (human)
Definition A proteasome subunit beta type-4 that is encoded in the genome of human.
Short Label hPSMB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P28070 (PSMB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
S9 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation HPRD   PhosphoSitePlus 20068231
S26 Phosphorylation PhosphoSitePlus   UniProt 23186163
T27 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y75 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
Y107 Phosphorylation PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
T236 O-Glycosylation GlyGen 29485866, 26374642, 34725712, ...33465208, 34229054
T236 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S249 O-Glycosylation GlyGen 33465208
S249 Phosphorylation PhosphoSitePlus
T250 O-Glycosylation GlyGen 33465208
T252 O-Glycosylation GlyGen 33465208
S261 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 F9 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S26 C26 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S26 Y26 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S30 P30 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S30 F30 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T46 A46 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S55 L55 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T238 N238 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S261 G261 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]