Protein Information

Cytoscape View


UniProt AC / UniProt ID P27987 / IP3KB_HUMAN
Protein Name Inositol-trisphosphate 3-kinase B
Gene Name Name: ITPKB
Organism Homo sapiens (Human)

PRO ID PR:P27987
DAG View
PRO Name inositol-trisphosphate 3-kinase B (human)
Definition An inositol-trisphosphate 3-kinase B that is encoded in the genome of human.
Short Label hITPKB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27987 (ITPKB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
R39 Methylation PhosphoSitePlus
S43 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087
S49 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087
R52 Methylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S65 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S71 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S174 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S176 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S182 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
Y770 Phosphorylation PhosphoSitePlus
Y854 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation HPRD 18669648, 18088087
S49 Phosphorylation HPRD 18669648, 18088087
S65 Phosphorylation HPRD 18669648
S71 Phosphorylation HPRD 18669648
S174 Phosphorylation HPRD 18669648
S176 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R39 K39 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S197 R197 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S197 N197 Biomuta DOID:363 / uterine cancer [ tcga ]
S204 F204 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S280 P280 Biomuta DOID:263 / kidney cancer [ tcga ]
S440 F440 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y770 H770 Biomuta DOID:0070003 / blastoma [ cosmic ]