iPTMnet Report for P27987 (ITPKB)
Protein Information
| UniProt AC / UniProt ID | P27987 / IP3KB_HUMAN |
| Protein Name | Inositol-trisphosphate 3-kinase B |
| Gene Name | Name: ITPKB |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P27987 |
| PRO Name | inositol-trisphosphate 3-kinase B (human) |
| Definition | An inositol-trisphosphate 3-kinase B that is encoded in the genome of human. |
| Short Label | hITPKB |
| Category | organism-gene |
DAG ViewP27987 (ITPKB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y4 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S31 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T33 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R39 | Methylation | score1 | PhosphoSitePlus | |||
| S43 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 18088087 | ||
| S49 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 18088087 | ||
| R52 | Methylation | score1 | PhosphoSitePlus | |||
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S65 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S71 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 19690332 | ||
| S84 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T118 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S120 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S174 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 18669648, 35039634 | ||
| S176 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S197 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S204 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S227 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S228 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S264 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S269 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S355 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S440 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C481 | Methylation | score1 | IEDB | 31844290 | ||
| T585 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S588 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y770 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y854 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S43 | Phosphorylation | score0 | HPRD | 18669648, 18088087 | ||
| S49 | Phosphorylation | score0 | HPRD | 18669648, 18088087 | ||
| S65 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S71 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S174 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S176 | Phosphorylation | score0 | HPRD | 18669648 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y4 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| Y4 | C4 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| R39 | K39 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| R52 | K52 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S197 | R197 | Biomuta | DOID:1324 / lung cancer [ icgc ] | |
| S197 | N197 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S204 | F204 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S228 | L228 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S440 | F440 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T585 | K585 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y770 | H770 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
