iPTMnet Report for P27986 (PIK3R1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27986 / P85A_HUMAN
Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Gene Name Name: PIK3R1
Synonyms:GRB1;
Organism Homo sapiens (Human)

PRO ID PR:P27986
DAG View
PRO Name phosphatidylinositol 3-kinase regulatory subunit alpha (human)
Definition A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human.
Short Label hPIK3R1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27986 (PIK3R1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S2 Acetylation UniProt 22814378
Y12 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
S83 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 25114970, 21743495, 17043656
T86 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 27478041
Y203 Phosphorylation P07949 (RET) neXtProt   PhosphoSitePlus 16153436
S208 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   UniProt 23186163
K346 Ubiquitination PhosphoSitePlus
Y368 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus 8385099
T369 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
Y452 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T454 Phosphorylation PhosphoSitePlus
K459 Sumoylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y470 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
Y504 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
Y508 Phosphorylation P09619 (PDGFRB) neXtProt   PhosphoSitePlus 8086421
K513 Ubiquitination PhosphoSitePlus
R514 Methylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
R523 Methylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K567 Ubiquitination PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation P06213 (INSR) phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19369195, 8385099
T603 Phosphorylation PhosphoSitePlus
Y607 Phosphorylation P06213 (INSR) , P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P 15592455, 8385099, 30550886
S608 Phosphorylation P42336 (PIK3CA) , P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 9446654, 23270540, 8313897, ...8628286, 19233141, 14729945
T623 Phosphorylation phospho.ELM 17081983
S628 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S652 Phosphorylation Q15139 (PRKD1) neXtProt 21825134
Y657 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
Y679 Phosphorylation PhosphoSitePlus
Y688 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 9461588, 11337495
S690 Phosphorylation RLIMS-P 22342344
Site PTM Type PTM Enzyme Score Source PMID
Y368 Phosphorylation P06213 (INSR) HPRD 8385099, 14729945
Y452 Phosphorylation HPRD 18083107
Y467 Phosphorylation HPRD 17016520, 18083107, 17389395
Y556 Phosphorylation HPRD 18083107
Y580 Phosphorylation P06213 (INSR) HPRD 17016520, 8385099, 16497976
Y607 Phosphorylation P06213 (INSR) HPRD 17016520, 17389395, 8385099, ...20068231
S608 Phosphorylation HPRD 14729945
S628 Phosphorylation HPRD 17081983
S629 Phosphorylation HPRD 17081983
Y688 Phosphorylation P06239 (LCK) HPRD 9461588
Site PTM Type PTM Enzyme Score Source PMID
Y98 Phosphorylation P06213 (INSR) HPRD 8385099, 14729945
Y182 Phosphorylation HPRD 18083107
Y197 Phosphorylation HPRD 17016520, 18083107, 17389395
Y286 Phosphorylation HPRD 18083107
Y310 Phosphorylation P06213 (INSR) HPRD 17016520, 8385099, 16497976
Y337 Phosphorylation P06213 (INSR) HPRD 17016520, 17389395, 8385099, ...20068231
S338 Phosphorylation HPRD 9446654, 8313897, 14729945
S358 Phosphorylation HPRD 17081983
S359 Phosphorylation HPRD 17081983
Y418 Phosphorylation P06239 (LCK) HPRD 9461588
Site PTM Type PTM Enzyme Score Source PMID
Y68 Phosphorylation P06213 (INSR) HPRD 8385099, 14729945
Y152 Phosphorylation HPRD 18083107
Y167 Phosphorylation HPRD 17016520, 18083107, 17389395
Y256 Phosphorylation HPRD 18083107
Y280 Phosphorylation P06213 (INSR) HPRD 17016520, 8385099, 16497976
Y307 Phosphorylation P06213 (INSR) HPRD 17016520, 17389395, 8385099, ...20068231
S308 Phosphorylation HPRD 9446654, 8313897, 14729945
S328 Phosphorylation HPRD 17081983
S329 Phosphorylation HPRD 17081983
Y388 Phosphorylation P06239 (LCK) HPRD 9461588


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048770 (hPIK3R1/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P27986 (PIK3R1) S608 P42336 (PIK3CA) decreased_association eFIP 14729945


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000002131 (hTEK/var:R849W) Interaction PR:P27986-1 (hPIK3R1/iso:1) PRO 10369874
PR:000002132 (hTEK/var:Y897S) Interaction PR:P27986-1 (hPIK3R1/iso:1) PRO 10369874
PR:000025834 (mSYK/iso:1/Phos:1) Interaction PR:P27986 (hPIK3R1) PRO 15536084


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 R43 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y59 C59 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y73 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y76 C76 Biomuta DOID:363 / uterine cancer [ icgc ]
S147 L147 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T148 I148 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y152 N152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y152 H152 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y152 C152 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y182 N182 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y182 H182 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y182 C182 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y203 C203 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y203 N203 Biomuta DOID:4159 / skin cancer [ cosmic ]
S208 Y208 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y280 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y280 N280 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y280 C280 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y280 D280 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S308 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y310 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y310 C310 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y310 N310 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y310 D310 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S329 G329 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S338 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S359 G359 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K379 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K379 N379 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K379 E379 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y388 C388 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y418 C418 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y452 N452 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y452 H452 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y452 C452 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T454 I454 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K459 E459 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y463 * Biomuta DOID:4159 / skin cancer [ cosmic, tcga ] DOID:1319 / brain cancer [ cosmic ]
Y463 C463 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y470 D470 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R514 L514 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R514 C514 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K519 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R523 S523 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R523 K523 Biomuta DOID:3571 / liver cancer [ cosmic ]
K567 E567 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
K567 T567 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T576 M576 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y580 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y580 N580 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y580 C580 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y580 D580 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S608 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S629 G629 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y688 C688 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S690 F690 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S690 P690 Biomuta DOID:3571 / liver cancer [ cosmic ]