Protein Information

Cytoscape View


UniProt AC / UniProt ID P27816 / MAP4_HUMAN
Protein Name Microtubule-associated protein 4
Gene Name Name: MAP4
Organism Homo sapiens (Human)

PRO ID PR:P27816
DAG View
PRO Name microtubule-associated protein 4 (human)
Definition A microtubule-associated protein 4 that is encoded in the genome of human.
Short Label hMAP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27816 (MAP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 20068231
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
T11 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 20068231
T28 Phosphorylation PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T57 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S68 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
T101 Phosphorylation PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S200 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S230 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
S280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 17693683, 17287340, 20068231
T282 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 18669648, ...20068231
T287 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S295 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
T354 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231, 17924679
K361 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
T380 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 17287340, 20068231, 17924679
K387 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K394 Acetylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus   UniProt 23186163
T442 Phosphorylation PhosphoSitePlus   UniProt 23186163
T451 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 23186163, 19690332, 20068231
S510 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T512 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T521 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 17287340, 18088087, 19690332, 20068231, 16964243
T526 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
K560 Ubiquitination PhosphoSitePlus
T565 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T571 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332, 20068231, 17081983
K574 Ubiquitination PhosphoSitePlus
S580 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T582 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T585 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S602 Phosphorylation phospho.ELM 18669648
S605 Phosphorylation phospho.ELM 18669648
S609 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
T620 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus   UniProt 20068231
T627 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K633 Acetylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
C635 S-Nitrosylation dbSNO 16648260, 22178444
S636 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 17287340, 20068231
S643 Phosphorylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
T686 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
S696 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10791892, 9398320, 23186163, ...15216889, 25232678, 25746230, 11683421
K702 Acetylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
T706 Phosphorylation PhosphoSitePlus
T712 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus   UniProt 23186163
K718 Acetylation PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus   UniProt 23186163
K726 Ubiquitination PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
S742 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S745 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S760 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S764 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S768 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 25746230, 31040780, 17287340, ...25232678
K784 Acetylation PhosphoSitePlus
S787 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10791892, 21406692, 9398320, ...23186163, 15216889, 25232678, 31040780, 11683421, 25746230, 20068231
S789 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
S797 O-Glycosylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus   UniProt 20068231
S803 Phosphorylation PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
T819 Phosphorylation PhosphoSitePlus
S822 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S823 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S825 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 16565220, ...18669648, 20068231
S827 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 16964243
T828 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K838 Acetylation PhosphoSitePlus
K838 Sumoylation PhosphoSitePlus
K847 Acetylation PhosphoSitePlus
K852 Acetylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus   UniProt 23186163
S859 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
K871 Acetylation PhosphoSitePlus
K871 Methylation PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
T874 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
T878 Phosphorylation PhosphoSitePlus
T892 Phosphorylation P06493 (CDK1) PhosphoSitePlus 10791892
S896 Phosphorylation PhosphoSitePlus
S899 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T900 Phosphorylation PhosphoSitePlus
T901 Phosphorylation P06493 (CDK1) PhosphoSitePlus 10791892
T909 Phosphorylation PhosphoSitePlus
K912 Acetylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
T917 Phosphorylation P06493 (CDK1) PhosphoSitePlus 10791892
T925 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus 21851590, 17287340
T927 Phosphorylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K933 Acetylation PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
K938 Acetylation PhosphoSitePlus
K938 Methylation PhosphoSitePlus
S941 Phosphorylation Q9P0L2 (MARK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 8631898, 21406692, ...20068231
T942 Phosphorylation PhosphoSitePlus   UniProt 21406692
K946 Ubiquitination PhosphoSitePlus
K955 Methylation PhosphoSitePlus
T960 Phosphorylation PhosphoSitePlus
T965 Phosphorylation PhosphoSitePlus
T977 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus
K991 Acetylation PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
S996 Phosphorylation PhosphoSitePlus
K997 Acetylation PhosphoSitePlus
K998 Acetylation PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
S1000 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 24275569
Y1001 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1002 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
K1011 Methylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
K1028 Acetylation PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
K1034 Acetylation PhosphoSitePlus
S1036 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1037 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1038 Acetylation PhosphoSitePlus
S1041 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1042 Acetylation PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1060 Acetylation PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
K1064 Methylation PhosphoSitePlus
K1070 Acetylation PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
S1073 Phosphorylation Q9P0L2 (MARK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18669648, 20068231, 8631898
T1142 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus   UniProt 21406692
T1150 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S14 Phosphorylation HPRD 20068231
Y47 Phosphorylation HPRD 15144186, 18707149
T57 Phosphorylation HPRD 18669648
S60 Phosphorylation HPRD 18669648
S68 Phosphorylation HPRD 20068231
T76 Phosphorylation HPRD 17081983
S94 Phosphorylation HPRD 19413330, 17081983
T96 Phosphorylation HPRD 17081983
T97 Phosphorylation HPRD 19413330, 17081983, 20068231
S99 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
T101 Phosphorylation HPRD 17081983
S163 Phosphorylation HPRD 20068231
S191 Phosphorylation HPRD 20068231
S197 Phosphorylation HPRD 17287340
S202 Phosphorylation HPRD 17287340
T216 Phosphorylation HPRD 20068231
T256 Phosphorylation HPRD 20068231
S280 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 18212344, 20230923, 15302935, 17693683, 19664994, 19007248, 18452278, 19651622, 18669648, 19664995, 18707149, 20166139, 17924679, 19415658, 20068231, 19691289
T282 Phosphorylation HPRD 17287340, 20230923, 18452278, ...18669648, 20166139, 19415658, 20068231
T287 Phosphorylation HPRD 17287340, 20068231
T354 Phosphorylation HPRD 17081983
S358 Phosphorylation HPRD 17081983
T380 Phosphorylation HPRD 20068231
S440 Phosphorylation HPRD 20068231
T442 Phosphorylation HPRD 20068231
T484 Phosphorylation HPRD 17081983, 20068231
S495 Phosphorylation HPRD 20068231
T496 Phosphorylation HPRD 20068231
S507 Phosphorylation HPRD 19413330, 17287340, 20230923, ...18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 20058876, 19415658, 20068231
S510 Phosphorylation HPRD 17322306, 19664994, 18452278, ...19651622, 18669648, 20068231
T512 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231, 18452278
T521 Phosphorylation HPRD 19413330, 18452278, 18088087, ...16964243, 18767875, 15302935, 19691289, 19664995, 19651622, 19664994, 18669648, 18707149, 18510355, 17287340, 20166139, 16565220, 17924679, 19415658, 20068231, 18212344
T526 Phosphorylation HPRD 19651622, 20068231, 17924679
T565 Phosphorylation HPRD 18669648
T571 Phosphorylation HPRD 19413330, 20058876, 16964243, ...18767875, 15302935, 19691289, 16565220, 19651622, 19664994, 18669648, 20068231
S580 Phosphorylation HPRD 18669648, 20068231
T582 Phosphorylation HPRD 19651622, 18669648, 20068231
T585 Phosphorylation HPRD 17322306, 19651622, 18669648, ...19664994, 20068231
S609 Phosphorylation HPRD 17287340
S624 Phosphorylation HPRD 19415658, 18452278
S636 Phosphorylation HPRD 17322306, 17287340, 19664994, ...19691289, 19651622, 18669648, 20166139, 20068231
T687 Phosphorylation HPRD 19664994, 20068231, 18452278
S696 Phosphorylation P06493 (CDK1) HPRD 9398320, 11683421, 20068231
T712 Phosphorylation HPRD 20068231
T714 Phosphorylation HPRD 20068231
T722 Phosphorylation HPRD 20068231
S745 Phosphorylation HPRD 17287340
S760 Phosphorylation HPRD 17287340
S764 Phosphorylation HPRD 17287340
S768 Phosphorylation HPRD 17287340, 20068231
S787 Phosphorylation P06493 (CDK1) HPRD 19691289, 19664995, 11683421, ...9398320, 19415658, 20068231
S789 Phosphorylation HPRD 19691289, 20068231
S793 Phosphorylation HPRD 20068231, 17924679
S797 Phosphorylation HPRD 20068231
T810 Phosphorylation HPRD 20068231
S822 Phosphorylation HPRD 18669648
S823 Phosphorylation HPRD 18669648, 20068231
S825 Phosphorylation HPRD 16964243, 19691289, 16565220, ...19651622, 18669648, 19007248, 20068231, 20068230
S827 Phosphorylation HPRD 19651622, 17287340, 16964243, ...20068231, 19691289
T828 Phosphorylation HPRD 17287340
S876 Phosphorylation HPRD 20068231
T878 Phosphorylation HPRD 20068231
S899 Phosphorylation HPRD 17287340
S914 Phosphorylation HPRD 20068231
S915 Phosphorylation HPRD 17924679
T917 Phosphorylation HPRD 17924679
T925 Phosphorylation HPRD 17287340, 18212344, 20068231
T927 Phosphorylation HPRD 20068231
S928 Phosphorylation Q9P0L2 (MARK1) HPRD 20166139, 18767875, 20058876, ...20068231, 8631898
S937 Phosphorylation HPRD 20068231
S941 Phosphorylation Q9P0L2 (MARK1) HPRD 20166139, 18669648, 20068231, ...8631898
T942 Phosphorylation HPRD 20068231
T960 Phosphorylation HPRD 20068231
T965 Phosphorylation HPRD 20068231
S1000 Phosphorylation HPRD 17287340
Y1001 Phosphorylation HPRD 17287340
S1036 Phosphorylation HPRD 18669648
S1037 Phosphorylation HPRD 18669648
S1041 Phosphorylation HPRD 18669648
S1073 Phosphorylation Q9P0L2 (MARK1) HPRD 18212344, 18707149, 18452278, ...19651622, 18669648, 20068231, 17693683, 20166139, 19415658, 8631898
T1150 Phosphorylation HPRD 20068231
S1151 Phosphorylation HPRD 19651622, 18669648, 19415658, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
T28 Phosphorylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
K519 Acetylation PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
K717 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T332 Phosphorylation PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1073 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S14 Phosphorylation HPRD 20068231
Y47 Phosphorylation HPRD 15144186, 18707149
T57 Phosphorylation HPRD 18669648
S60 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 I28 Biomuta DOID:363 / uterine cancer [ tcga ]
T41 I41 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T57 P57 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S68 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T76 N76 Biomuta DOID:3571 / liver cancer [ icgc ]
S94 I94 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T101 I101 Biomuta DOID:1909 / melanoma [ cosmic ]
K262 N262 Biomuta DOID:363 / uterine cancer [ tcga ]
S330 L330 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
K332 T332 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S358 Y358 Biomuta DOID:363 / uterine cancer [ tcga ]
K387 Q387 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S439 P439 Biomuta DOID:263 / kidney cancer [ cosmic ]
S439 F439 Biomuta DOID:4159 / skin cancer [ icgc ]
T451 P451 Biomuta DOID:363 / uterine cancer [ tcga ]
S510 * Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S605 F605 Biomuta DOID:1909 / melanoma [ tcga ]
K634 R634 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T714 I714 Biomuta DOID:363 / uterine cancer [ tcga ]
K718 R718 Biomuta DOID:1324 / lung cancer [ tcga ]
S723 F723 Biomuta DOID:1909 / melanoma [ cosmic ]
S760 P760 Biomuta DOID:3571 / liver cancer [ tcga ]
T810 N810 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K838 N838 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T892 I892 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K938 N938 Biomuta DOID:363 / uterine cancer [ tcga ]
T942 M942 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S1010 F1010 Biomuta DOID:1909 / melanoma [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1151 R1151 Biomuta DOID:3571 / liver cancer [ icgc ]