Protein Information

Cytoscape View


UniProt AC / UniProt ID P27797 / CALR_HUMAN
Protein Name Calreticulin precursor
Gene Name Name: CALR
Synonyms:CRTC;
Organism Homo sapiens (Human)

PRO ID PR:P27797
DAG View
PRO Name calreticulin (human)
Definition A calreticulin that is encoded in the genome of human.
Short Label hCALR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27797 (CALR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus   UniProt 19608861
K48 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
R73 Methylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
C105 S-Nitrosylation dbSNO 25040305, 2212679, 22126794, ...26338901
Y109 Phosphorylation PhosphoSitePlus
K111 Methylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K159 Acetylation PhosphoSitePlus   UniProt 19608861
K159 Ubiquitination PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K209 Acetylation PhosphoSitePlus   UniProt 19608861
K209 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
R222 Methylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Methylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
N344 N-Glycosylation UniProt 19159218
K351 Ubiquitination PhosphoSitePlus
R366 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 N55 Biomuta DOID:3571 / liver cancer [ icgc ]
K62 R62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K62 N62 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K64 T64 Biomuta DOID:1909 / melanoma [ cosmic ]
S85 I85 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K111 N111 Biomuta DOID:3571 / liver cancer [ icgc ]
K143 T143 Biomuta DOID:363 / uterine cancer [ tcga ]
Y150 H150 Biomuta DOID:263 / kidney cancer [ tcga ]
K151 N151 Biomuta DOID:1612 / breast cancer [ tcga ]
K206 N206 Biomuta DOID:363 / uterine cancer [ tcga ]
S214 L214 Biomuta DOID:1324 / lung cancer [ tcga ]
R222 W222 Biomuta DOID:363 / uterine cancer [ tcga ]
S300 Y300 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]