iPTMnet Report for P27708 (CAD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27708 / PYR1_HUMAN
Protein Name CAD protein
Gene Name Name: CAD
Organism Homo sapiens (Human)

PRO ID PR:P27708
DAG View
PRO Name CAD protein (human)
Definition A CAD protein that is encoded in the genome of human.
Short Label hCAD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27708 (CAD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S10 Phosphorylation HPRD   PhosphoSitePlus 20068231
K127 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
T172 Phosphorylation HPRD   PhosphoSitePlus 20068231
R177 Methylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Methylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
C252 Methylation IEDB 31844290
Y267 Phosphorylation PhosphoSitePlus
C288 Methylation IEDB 31844290
S292 Phosphorylation IEDB 32387766
T375 Phosphorylation HPRD 18767875
K424 Ubiquitination PhosphoSitePlus
T456 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12438317, 15890648, 10659854, ...17206380, 14991569, 17485345
T475 Phosphorylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
T723 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 29351928, 35132862, 35083852, 32119511, 34229054
T726 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 29351928, 35132862, 35083852, 32119511, 34229054
Y735 Phosphorylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K747 Acetylation PhosphoSitePlus   UniProt 19608861
K747 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
C787 Methylation IEDB 31844290
K795 Ubiquitination PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
T883 Phosphorylation PhosphoSitePlus
T1037 Phosphorylation P27708 (CAD) HPRD 11986331, 12438317
S1038 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S1044 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation HPRD 20068231
C1078 Methylation IEDB 31844290
T1080 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 29351928, 35132862, 35083852, 32119511, 34229054
S1112 Phosphorylation PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
K1177 Ubiquitination PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
K1211 Ubiquitination PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
C1296 Methylation IEDB 31844290
K1301 Methylation PhosphoSitePlus
K1309 Ubiquitination PhosphoSitePlus
K1313 Ubiquitination PhosphoSitePlus
K1323 Ubiquitination PhosphoSitePlus
K1325 Ubiquitination PhosphoSitePlus
C1374 Methylation IEDB 31844290
K1387 Ubiquitination PhosphoSitePlus
S1406 Phosphorylation P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 23186163, ...11986331, 18669648, 17206380, 14991569, 4092695, 17485345, 20068231
S1407 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1410 Phosphorylation PhosphoSitePlus
K1411 Acetylation PhosphoSitePlus   UniProt 19608861
K1411 Ubiquitination PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
K1431 Ubiquitination PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
K1450 Sumoylation PhosphoSitePlus
K1450 Ubiquitination PhosphoSitePlus
K1460 Ubiquitination PhosphoSitePlus
K1521 Ubiquitination PhosphoSitePlus
C1529 Methylation IEDB 31844290
K1618 Ubiquitination PhosphoSitePlus
K1625 Ubiquitination PhosphoSitePlus
S1646 Phosphorylation PhosphoSitePlus
K1657 Ubiquitination PhosphoSitePlus
S1698 Phosphorylation PhosphoSitePlus
S1724 Phosphorylation PhosphoSitePlus
K1778 Ubiquitination PhosphoSitePlus
Y1794 Phosphorylation PhosphoSitePlus
Y1805 Phosphorylation PhosphoSitePlus
S1823 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17081983
T1827 Phosphorylation PhosphoSitePlus
S1828 Phosphorylation PhosphoSitePlus
T1831 Phosphorylation PhosphoSitePlus
T1832 Phosphorylation PhosphoSitePlus
T1833 Phosphorylation PhosphoSitePlus
R1839 Methylation PhosphoSitePlus
H1856 Phosphorylation PhosphoSitePlus
S1859 Phosphorylation P17612 (PRKACA) , P23443 (RPS6KB1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 23186163, ...16964243, 18767875, 17206380, 19664994, 19664995, 19651622, 17322306, 18669648, 23429704, 23429703, 24275569, 18707149, 14991569, 4092695, 17485345, 20068231, 17081983
S1873 Phosphorylation UniProt 17485345
T1884 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
T1888 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 29351928, 35132862, 35083852, 32119511, 34229054
T1888 Phosphorylation PhosphoSitePlus
C1889 S-Nitrosylation dbSNO 26338901
Y1890 Phosphorylation PhosphoSitePlus
S1900 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 23429703, 20068231
T1906 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1914 Phosphorylation PhosphoSitePlus
S1920 Phosphorylation HPRD 17081983
S1938 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1946 Phosphorylation PhosphoSitePlus
K1953 Ubiquitination PhosphoSitePlus
K1961 Ubiquitination PhosphoSitePlus
K2036 Ubiquitination PhosphoSitePlus
Y2103 Phosphorylation PhosphoSitePlus
K2125 Ubiquitination PhosphoSitePlus
S2154 Phosphorylation PhosphoSitePlus
T2155 Phosphorylation PhosphoSitePlus
Y2158 Phosphorylation PhosphoSitePlus
K2178 Ubiquitination PhosphoSitePlus
Y2203 Phosphorylation PhosphoSitePlus
Y2212 Phosphorylation PhosphoSitePlus
T2220 Phosphorylation PhosphoSitePlus


P27708 (CAD) as PTM Enzyme



Substrate Site Score Source PMID
P27708 (CAD) T1037 HPRD 11986331, 12438317


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S133 Y133 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R177 W177 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R177 Q177 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
R177 L177 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C252 Y252 Biomuta DOID:263 / kidney cancer [ cosmic ]
C252 F252 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C288 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
C288 F288 Biomuta DOID:3571 / liver cancer [ cosmic ]
T375 S375 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T475 A475 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K490 R490 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T585 S585 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y735 C735 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K739 N739 Biomuta DOID:4159 / skin cancer [ cosmic ]
K747 R747 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K754 N754 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K778 R778 Biomuta DOID:1612 / breast cancer [ cosmic ]
K867 R867 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1038 F1038 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1044 L1044 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1112 C1112 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1211 N1211 Biomuta DOID:363 / uterine cancer [ icgc ]
R1839 H1839 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
H1856 Y1856 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1946 R1946 Biomuta DOID:263 / kidney cancer [ cosmic ]