Protein Information

Cytoscape View


UniProt AC / UniProt ID P27707 / DCK_HUMAN
Protein Name Deoxycytidine kinase
Gene Name Name: DCK
Organism Homo sapiens (Human)

PRO ID PR:P27707
DAG View
PRO Name deoxycytidine kinase (human)
Definition A deoxycytidine kinase that is encoded in the genome of human.
Short Label hDCK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27707 (DCK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD   PhosphoSitePlus 18691976
S8 Phosphorylation HPRD   PhosphoSitePlus 18691976
C9 S-Nitrosylation dbSNO 26338901
S11 Phosphorylation P48730 (CSNK1D) HPRD   PhosphoSitePlus   UniProt 18691976, 20637175
S13 Phosphorylation HPRD   PhosphoSitePlus 18691976
S15 Phosphorylation P48730 (CSNK1D) HPRD   PhosphoSitePlus   UniProt 18691976, 20637175
S16 Phosphorylation PhosphoSitePlus
T19 Phosphorylation HPRD   PhosphoSitePlus 20068231
K23 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
T64 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18077418
T72 Phosphorylation P48730 (CSNK1D) HPRD   PhosphoSitePlus   UniProt 18077418, 20637175
S74 Phosphorylation Q13535 (ATR) , Q13315 (ATM) , P48730 (CSNK1D) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 17525332, 23186163, ...22490700, 20230923, 18077418, 26620371, 18669648, 20637175, 17350163, 20068231, 22850745
K76 Ubiquitination PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 N8 Biomuta DOID:10534 / stomach cancer [ tcga ]
K23 N23 Biomuta DOID:363 / uterine cancer [ tcga ]
S63 T63 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T72 A72 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
T72 K72 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K115 T115 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K252 M252 Biomuta DOID:1324 / lung cancer [ icgc ]
K252 N252 Biomuta DOID:3571 / liver cancer [ icgc ]