iPTMnet Report for P27695 (APEX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27695 / APEX1_HUMAN
Protein Name DNA-(apurinic or apyrimidinic site) endonuclease
Gene Name Name: APEX1
Synonyms:APE,APE1,APEX,APX,HAP1,REF1;
Organism Homo sapiens (Human)

PRO ID PR:P27695
DAG View
PRO Name DNA-(apurinic or apyrimidinic site) endonuclease (human)
Definition A DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human.
Short Label hAPEX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27695 (APEX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
K6 Acetylation PhosphoSitePlus   UniProt 14633989
K6 Methylation PhosphoSitePlus
K7 Acetylation PhosphoSitePlus   UniProt 14633989
K7 Ubiquitination PhosphoSitePlus
R18 Methylation PhosphoSitePlus
T19 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 35083852, 34931806, 32119511, 28510447
T19 Phosphorylation PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K27 Acetylation PhosphoSitePlus   UniProt 20699270
K27 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus   UniProt 20699270
K32 Acetylation PhosphoSitePlus   UniProt 20699270
K35 Acetylation PhosphoSitePlus   UniProt 20699270
Y45 Phosphorylation PhosphoSitePlus
K52 Sumoylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T53 Phosphorylation neXtProt 20473298
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
S56 Phosphorylation PhosphoSitePlus
K58 Methylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K63 Methylation PhosphoSitePlus
C65 S-Nitrosylation dbSNO 17403694, 22178444
S66 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Sumoylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
C93 S-Nitrosylation dbSNO 17403694, 22178444
K98 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S123 Phosphorylation HPRD   PhosphoSitePlus 10023679
S123 Phosphorylation P68400 (CSNK2A1) HPRD 10023679
K125 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
R136 Methylation PhosphoSitePlus
C138 Methylation IEDB 31844290
R156 Methylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation HPRD   PhosphoSitePlus 20068230
K197 Acetylation PhosphoSitePlus   UniProt 19608861
K197 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T233 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P+ 20473298, 21727086
T233 Phosphorylation Q00535 (CDK5) RLIMS-P+ 21727086
S252 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation HPRD   PhosphoSitePlus 15592455
S290 Phosphorylation phospho.ELM 10023679
R301 Methylation PhosphoSitePlus
C310 Methylation IEDB 31844290
C310 S-Nitrosylation dbSNO 17403694, 22178444


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K3 R3 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K7 R7 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K35 Q35 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K58 N58 Biomuta DOID:3571 / liver cancer [ cosmic ]
C65 S65 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S123 L123 Biomuta DOID:1612 / breast cancer [ icgc ]
R136 C136 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R136 S136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R156 Q156 Biomuta DOID:1324 / lung cancer [ cosmic ]
T233 M233 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R301 H301 Biomuta DOID:4606 / bile duct cancer [ cosmic ]