Protein Information

Cytoscape View


UniProt AC / UniProt ID P27540 / ARNT_HUMAN
Protein Name Aryl hydrocarbon receptor nuclear translocator
Gene Name Name: ARNT
Synonyms:BHLHE2;
Organism Homo sapiens (Human)

PRO ID PR:P27540
DAG View
PRO Name aryl hydrocarbon receptor nuclear translocator (human)
Definition An aryl hydrocarbon receptor nuclear translocator that is encoded in the genome of human.
Short Label hARNT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27540 (ARNT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
T11 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S77 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 16129408
S82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
R143 Methylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus
T638 Phosphorylation PhosphoSitePlus
T640 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation HPRD 19664994
S77 Phosphorylation P68400 (CSNK2A1) HPRD 18669648, 16129408
Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation HPRD 19664994


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16665 (HIF1A) S247 P27540 (ARNT) inhibited_association eFIP 20699359


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 E2 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K58 T58 Biomuta DOID:363 / uterine cancer [ tcga ]
K58 N58 Biomuta DOID:363 / uterine cancer [ tcga ]
R143 L143 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K417 R417 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S788 L788 Biomuta DOID:11934 / head and neck cancer [ tcga ]