iPTMnet Report for P27448 (MARK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27448 / MARK3_HUMAN
Protein Name MAP/microtubule affinity-regulating kinase 3
Gene Name Name: MARK3
Synonyms:CTAK1,EMK2;
Organism Homo sapiens (Human)

PRO ID PR:P27448
DAG View
PRO Name MAP/microtubule affinity-regulating kinase 3 (human)
Definition A MAP/microtubule affinity-regulating kinase 3 that is encoded in the genome of human.
Short Label hMARK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27448 (MARK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus   UniProt 19369195
S45 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
T90 Phosphorylation Signor 15319445
T90 Phosphorylation P11309 (PIM1) Signor 15319445
T95 Phosphorylation Signor 15319445
T95 Phosphorylation P11309 (PIM1) Signor 15319445
S96 Phosphorylation Signor 15319445
S96 Phosphorylation P11309 (PIM1) Signor 15319445
S164 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus   Signor   UniProt 12879020, 14976552
T211 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 12879020, 14976552
S215 Phosphorylation PhosphoSitePlus   Signor 12879020, 14976552
S215 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 12879020, 14976552
K227 Ubiquitination PhosphoSitePlus
S238 Phosphorylation phospho.ELM 14976552
K294 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus   UniProt 23186163
S377 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 23186163
S383 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
L384 Phosphorylation UniProt 18691976
S396 Phosphorylation PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus   UniProt 18691976
R407 Phosphorylation UniProt 18691976
Y418 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y432 Phosphorylation PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195
S476 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
T507 Phosphorylation neXtProt   PhosphoSitePlus 21644927
T507 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 21644927
Y508 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T530 Phosphorylation phospho.ELM 18220336
T536 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus   UniProt 23186163
T541 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 18220336
S563 Phosphorylation phospho.ELM 18220336
T564 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15084291, 18220336
T564 Phosphorylation P41743 (PRKCI) PhosphoSitePlus 15084291
T564 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor 15084291
T574 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus   UniProt 23186163
S585 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus   UniProt 18691976
R599 Methylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus   UniProt 23186163
S606 Phosphorylation phospho.ELM 18669648
K607 Acetylation IEDB 34357683
S610 Phosphorylation phospho.ELM 18669648
K611 Ubiquitination PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S657 Phosphorylation PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
Y690 Phosphorylation PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T234 Phosphorylation neXtProt 14976552
Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus 15319445
T90 Phosphorylation P11309 (PIM1) PhosphoSitePlus 15319445
T95 Phosphorylation PhosphoSitePlus 15319445
T95 Phosphorylation P11309 (PIM1) PhosphoSitePlus 15319445
S96 Phosphorylation PhosphoSitePlus 15319445
S96 Phosphorylation P11309 (PIM1) PhosphoSitePlus 15319445
T211 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
S520 Phosphorylation phospho.ELM 18220336
T536 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus 15319445
S598 Phosphorylation P27448-3 (MARK3) PhosphoSitePlus 15319445
S601 Phosphorylation PhosphoSitePlus 15319445
S601 Phosphorylation P27448-3 (MARK3) PhosphoSitePlus 15319445
T602 Phosphorylation PhosphoSitePlus 15319445
T602 Phosphorylation P27448-3 (MARK3) PhosphoSitePlus 15319445
S606 Phosphorylation PhosphoSitePlus 15319445
S606 Phosphorylation P27448-3 (MARK3) PhosphoSitePlus 15319445
Site PTM Type PTM Enzyme Score Source PMID
S384 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus


P27448 (MARK3) as PTM Enzyme



Substrate Site Score Source PMID
P27448-3 (MARK3) S598 PhosphoSitePlus 15319445
P27448-3 (MARK3) S601 PhosphoSitePlus 15319445
P27448-3 (MARK3) T602 PhosphoSitePlus 15319445
P27448-3 (MARK3) S606 PhosphoSitePlus 15319445
P30307-1 (CDC25C) S216 HPRD   PhosphoSitePlus 9543386, 10557092, 9278512, ...11333986, 11551930, 10786669, 20068231
P41236 (PPP1R2) S72 PhosphoSitePlus 25028520
Q8WUI4 (HDAC7) S155 neXtProt 16980613
Q99689 (FEZ1) S58 RLIMS-P+ 27247180


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 N3 Biomuta DOID:1612 / breast cancer [ icgc ]
K64 N64 Biomuta DOID:363 / uterine cancer [ icgc ]
T211 M211 Biomuta DOID:363 / uterine cancer [ icgc ]
T211 R211 Biomuta DOID:4159 / skin cancer [ cosmic ]
T234 R234 Biomuta DOID:4159 / skin cancer [ cosmic ]
T234 M234 Biomuta DOID:363 / uterine cancer [ icgc ]
S380 C380 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S383 L383 Biomuta DOID:4159 / skin cancer [ cosmic ]
T397 S397 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R407 I407 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
Y418 C418 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S456 G456 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S458 I458 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S511 N511 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T536 S536 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S546 I546 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S563 I563 Biomuta DOID:363 / uterine cancer [ cosmic ]
R599 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S610 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S643 P643 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y690 C690 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S724 A724 Biomuta DOID:363 / uterine cancer [ icgc ]