Protein Information

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UniProt AC / UniProt ID P27361 / MK03_HUMAN
Protein Name Mitogen-activated protein kinase 3
Gene Name Name: MAPK3
Synonyms:ERK1,PRKM3;
Organism Homo sapiens (Human)

PRO ID PR:P27361
DAG View
PRO Name mitogen-activated protein kinase 3 (human)
Definition A mitogen-activated protein kinase 3 that is encoded in the genome of human.
Short Label hMAPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27361 (MAPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K32 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus   UniProt 19369195
T202 Phosphorylation Q02750 (MAP2K1) , P36507 (MAP2K2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24300666, 28120452, 26043921, ...23977025, 16814113, 20429916, 17192257, 7687743, 27119567, 29476223, 23056203, 15939799, 28387310, 24521094, 26983806, 23237355, 24086495, 29487329, 8226933, 22096605, 23620784, 23686305, 23186163, 20485667, 1411546, 17662305, 24065881, 22815910, 22909302, 28592839, 22347457, 24810160, 21406692, 19412549, 19574994, 25849721, 24853429, 25722974, 18669648, 15466476, 22031842, 25733818, 26379399, 21210654, 16585161, 27134571, 26945908, 26716515, 26046303, 26919095, 24244431, 27054717, 26580203, 12138104, 26400984, 27304216, 9677429, 24833778, 20957203, 18775472, 21187008, 20226096, 11971971, 21596018, 21898401, 21129151, 19690332, 25179402, 20509944, 8626767, 24291038, 27533246, 19188252, 16009706, 16484360, 26441204, 23353780
Y204 Phosphorylation P27361 (MAPK3) , O60674 (JAK2) , Q02750 (MAP2K1) , P07949 (RET) , P06239 (LCK) , P36507 (MAP2K2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18983981, 28120452, 23977025, ...16814113, 24300666, 20429916, 17998336, 19494114, 8444886, 27119567, 29476223, 23056203, 15939799, 28387310, 24521094, 26983806, 23237355, 24086495, 29487329, 8226933, 22096605, 23620784, 23686305, 23186163, 20485667, 1411546, 17662305, 24065881, 22815910, 22909302, 28592839, 16464493, 22347457, 24810160, 21406692, 19412549, 19574994, 25849721, 24853429, 25722974, 18669648, 17192257, 15466476, 22031842, 25733818, 26379399, 21210654, 16585161, 27134571, 26945908, 7867743, 26716515, 26046303, 26919095, 24244431, 27054717, 26580203, 12138104, 26400984, 27304216, 9677429, 24833778, 17081983, 20957203, 18775472, 21898401, 21187008, 20226096, 11971971, 1835084, 7687743, 21129151, 19690332, 18083107, 25179402, 20509944, 8626767, 16153436, 27533246, 19188252, 16009706, 21596018, 26441204, 23353780
T207 Phosphorylation Q02750 (MAP2K1) , P27361 (MAPK3) PhosphoSitePlus   Signor   UniProt 19060905, 26823016
Y210 Phosphorylation Q02750 (MAP2K1) PhosphoSitePlus 26823016
R211 Methylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K302 Methylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
R309 Methylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K361 Methylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T202 Phosphorylation P27361 (MAPK3) , P36507 (MAP2K2) HPRD   PRO 18691976, 17389395, 7687743, ...17192257, 19651622, 18669648, 8626767
Y204 Phosphorylation P36507 (MAP2K2) , P27361 (MAPK3) HPRD   PRO 19901323, 15580310, 17389395, ...18691976, 17192257, 19651622, 18669648, 18707149, 20068231, 16497976
Site PTM Type PTM Enzyme Score Source PMID
T202 Phosphorylation P27361 (MAPK3) HPRD 19651622, 18691976, 18669648, ...17389395, 17192257
Y204 Phosphorylation HPRD 19901323, 15580310, 17389395, ...18691976, 19651622, 18669648, 18707149, 20068231, 16497976
S343 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26459638


P27361 (MAPK3) as PTM Enzyme



Substrate Site Score Source PMID
C9JLW8 (MCRIP1) S21 PhosphoSitePlus 25728771
C9JLW8 (MCRIP1) T30 PhosphoSitePlus 25728771
O00213 (APBB1) S175 Signor 14697653
O00213 (APBB1) S287 Signor 14697653
O00213 (APBB1) S347 Signor 14697653
O00213 (APBB1) T709 Signor 14697653
O00429 (DNM1L) S616 PhosphoSitePlus 25658204
O14994 (SYN3) S470 neXtProt   phospho.ELM   Signor 14732590
O43521 (BCL2L11) S69 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17525735, 15486195, 14555991, ...14681225
O43524 (FOXO3) S294 PhosphoSitePlus   Signor 18204439, 19282669
O43524 (FOXO3) S344 PhosphoSitePlus   Signor 18204439, 19282669
O43524 (FOXO3) S425 PhosphoSitePlus   Signor 18204439, 19282669
O43561-2 (LAT) T155 PhosphoSitePlus 15192708
O43561 (LAT) T184 Signor 15192708
O60244 (MED14) S986 PhosphoSitePlus 24049075
O60331 (PIP5K1C) S650 PhosphoSitePlus 15738269
O60674 (JAK2) S523 Signor 16705159
O75030-9 (MITF) S73 PhosphoSitePlus 20701798
O75581 (LRP6) S1490 PhosphoSitePlus 22558232
O75581 (LRP6) T1572 PhosphoSitePlus 22558232
O75582 (RPS6KA5) S360 phospho.ELM   PhosphoSitePlus   Signor 15568999
O75582-2 (RPS6KA5) S376 HPRD 19651622, 11994045, 20068231
O75582-1 (RPS6KA5) T581 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11994045, 17117922, 15568999
O75582 (RPS6KA5) T700 neXtProt 17117922
O95644 (NFATC1) S172 neXtProt   PhosphoSitePlus   Signor 10652349
O95997 (PTTG1) S165 Signor 10906323
P00533 (EGFR) T693 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 1939237, 1651322
P01100 (FOS) T232 phospho.ELM   Signor 7816602
P01100 (FOS) T325 phospho.ELM   Signor 12972619
P01100 (FOS) T331 phospho.ELM   Signor 12972619
P01100 (FOS) S374 Signor 12972619
P02686 (MBP) S96 neXtProt 1699809
P02686 (MBP) T232 phospho.ELM   PhosphoSitePlus   Signor 1939237, 16401070
P03372 (ESR1) S104 PhosphoSitePlus   Signor 17615152, 18372406
P03372 (ESR1) S106 PhosphoSitePlus   Signor 17615152, 18372406
P03372 (ESR1) S118 phospho.ELM   PhosphoSitePlus   Signor 17615152, 18372406, 15059947, ...7491495, 12466266
P04049 (RAF1) S289 neXtProt   PhosphoSitePlus   Signor 16407412
P04049 (RAF1) S296 neXtProt   PhosphoSitePlus   Signor 16407412
P04049 (RAF1) S301 neXtProt   PhosphoSitePlus   Signor 16407412
P04150 (NR3C1) S226 PhosphoSitePlus   Signor 20047289, 19812390, 17440046, ...12351702
P04637 (TP53) S15 neXtProt   PhosphoSitePlus   Signor 10781582, 12955074, 10958792
P04637 (TP53) S392 PhosphoSitePlus 25767119
P05412 (JUN) S63 Signor 12169099
P05412 (JUN) S73 Signor 12169099
P05787-1 (KRT8) S74 HPRD 9211903, 18691976, 11788583, ...19007248, 11781324
P05787 (KRT8) S432 HPRD   phospho.ELM   PhosphoSitePlus   Signor 9054461, 22344252, 18669648, ...9524113, 11788583
P06239 (LCK) S42 phospho.ELM   Signor 8226850, 8506364
P06239 (LCK) S59 HPRD   neXtProt   PhosphoSitePlus   Signor 8618896, 8226850, 8506364
P06401 (PGR) S294 phospho.ELM   PhosphoSitePlus   Signor 17717077, 10655479, 12529413
P07101-3 (TH) S31 PhosphoSitePlus 7901013
P07101-4 (TH) S35 PhosphoSitePlus 7901013
P07101-2 (TH) S58 PhosphoSitePlus 7901013
P07101 (TH) S62 neXtProt   PhosphoSitePlus   Signor 7901013, 1347949, 11359875
P08047 (SP1) S59 neXtProt   PhosphoSitePlus   Signor 19318349
P08047 (SP1) T453 HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 14593115, 20882567, 14744793, ...11904305
P08047 (SP1) T739 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19318349, 14593115, 14744793, ...11904305
P09917 (ALOX5) S664 neXtProt 12205041
P10242 (MYB) S532 phospho.ELM   PhosphoSitePlus   Signor 8798443, 8960373
P10275 (AR) S516 PhosphoSitePlus 18511414
P10275 (AR) S651 PhosphoSitePlus 16282370
P10415 (BCL2) T56 PhosphoSitePlus   Signor 10669763
P10415 (BCL2) S70 neXtProt   Signor 10669763, 10677502
P10415 (BCL2) T74 PhosphoSitePlus   Signor 10669763
P10415 (BCL2) S87 PhosphoSitePlus 10669763
P10636-8 (MAPT) S46 PhosphoSitePlus 9614189
P10636-8 (MAPT) T50 PhosphoSitePlus 9614189
P10636-8 (MAPT) T153 neXtProt   PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) T175 PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) T181 PhosphoSitePlus 9614189, 12801934
P10636-8 (MAPT) S199 PhosphoSitePlus 9614189
P10636-8 (MAPT) S202 neXtProt   PhosphoSitePlus 10090741, 9614189, 12801934
P10636-8 (MAPT) T205 neXtProt   PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) T212 neXtProt   PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) T217 PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) T231 neXtProt   PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) S235 neXtProt   PhosphoSitePlus 10090741, 9614189
P10636-8 (MAPT) S396 PhosphoSitePlus 9614189
P10636-8 (MAPT) S404 neXtProt   PhosphoSitePlus 9614189
P10636-8 (MAPT) S422 PhosphoSitePlus 10090741, 9614189
P10828 (THRB) S142 phospho.ELM   PhosphoSitePlus   Signor 12809513
P11362 (FGFR1) S777 neXtProt   PhosphoSitePlus   Signor 23405013
P11388 (TOP2A) S1213 phospho.ELM   PhosphoSitePlus 7635160
P11388 (TOP2A) S1247 phospho.ELM   PhosphoSitePlus 7635160
P11388 (TOP2A) S1354 phospho.ELM   PhosphoSitePlus 7635160
P11388 (TOP2A) S1361 phospho.ELM   PhosphoSitePlus 7635160
P11388 (TOP2A) S1393 phospho.ELM   PhosphoSitePlus 7635160
P12980 (LYL1) S36 neXtProt   PhosphoSitePlus 20844761
P13631 (RARG) S77 neXtProt 10748061
P13631 (RARG) S79 neXtProt   PhosphoSitePlus 10748061
P14598 (NCF1) S345 phospho.ELM   PhosphoSitePlus   Signor 8626435, 15629715, 16778989
P14598 (NCF1) S348 phospho.ELM   PhosphoSitePlus 8626435, 15629715
P14784 (IL2RB) T476 PhosphoSitePlus 26152718
P14921 (ETS1) T38 HPRD   neXtProt   Signor 12048211, 11948414
P15036 (ETS2) T72 neXtProt 11027273
P15056 (BRAF) S151 RLIMS-P+ 21478863
P15056 (BRAF) T401 neXtProt   PhosphoSitePlus 21135229
P15056 (BRAF) T753 PhosphoSitePlus   Signor 19933846, 16508002
P15336 (ATF2) T69 PhosphoSitePlus   Signor 12110590, 20068231, 7737129
P15336 (ATF2) T71 PhosphoSitePlus   Signor 12110590, 20068231, 7737129
P15923-1 (TCF3) T355 HPRD 14592976
P15976 (GATA1) S26 neXtProt 15967790
P16144 (ITGB4) S1356 PhosphoSitePlus 20870721
P16220 (CREB1) S133 RLIMS-P+ 23494562
P16949 (STMN1) S25 HPRD   neXtProt   PhosphoSitePlus   Signor 11135364, 16964243, 17693683, ...8245003, 18707149, 8125092, 18212344, 20230923, 18452278, 19413330, 8325880, 18767875, 20058876, 19651622, 8376365, 18491316, 17287340, 19664994, 19664995, 18669648, 9731215, 19415658, 20068231, 17924679
P16949 (STMN1) S38 neXtProt   PhosphoSitePlus   Signor 8325880, 8245003, 9731215
P17302 (GJA1) S255 HPRD   neXtProt   Signor 19664994, 9535909, 12637502, ...8631994
P17302 (GJA1) S279 HPRD   neXtProt   Signor 9535905, 9535909, 12637502, ...8631994
P17302 (GJA1) S282 HPRD   neXtProt   Signor 9535905, 9535909, 8631994
P17480 (UBTF) T117 HPRD   neXtProt   phospho.ELM   Signor 11741541
P17480 (UBTF) T201 HPRD   neXtProt   phospho.ELM   Signor 18669648, 11741541, 19007248, ...20068231
P17535 (JUND) S100 Signor 22327296
P17542-1 (TAL1) S122 HPRD   phospho.ELM   PhosphoSitePlus   Signor 19651622, 11904294, 8423803
P17600 (SYN1) S62 neXtProt 8622996
P17600 (SYN1) S67 neXtProt 8622996
P17600 (SYN1) S551 neXtProt 8622996
P17655 (CAPN2) S50 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14993287
P17676 (CEBPB) T235 phospho.ELM   PhosphoSitePlus   Signor 19327116, 12213825, 19723873
P17861 (XBP1) S68 PhosphoSitePlus 23277279
P17861 (XBP1) S181 PhosphoSitePlus 23277279
P18545 (PDE6G) T22 HPRD 12624098
P19419 (ELK1) S324 Signor 7889942
P19419 (ELK1) T336 Signor 7889942
P19419 (ELK1) S383 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8548291, 8262053, 11896587, ...7889942, 20675591
P19419 (ELK1) S389 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8548291, 8262053, 7889942
P19419 (ELK1) S422 Signor 7889942
P19793 (RXRA) S260 phospho.ELM   PhosphoSitePlus   Signor 10377179, 12048211
P20339 (RAB5A) S123 neXtProt   PhosphoSitePlus 10403367
P23396 (RPS3) T42 phospho.ELM   PhosphoSitePlus   Signor 17560175, 15950189
P23443 (RPS6KB1) S434 neXtProt 11279232
P24928 (POLR2A) S1619 phospho.ELM   Signor 14662762, 12721286
P24928 (POLR2A) S1626 Signor 14662762
P24928 (POLR2A) S1647 Signor 14662762
P24928 (POLR2A) S1654 Signor 14662762
P24928 (POLR2A) S1668 Signor 14662762
P24928 (POLR2A) S1675 Signor 14662762
P24928 (POLR2A) S1696 Signor 14662762
P24928 (POLR2A) S1717 Signor 14662762
P24928 (POLR2A) S1724 Signor 14662762
P24928 (POLR2A) S1738 Signor 14662762
P24928 (POLR2A) S1766 Signor 14662762
P24928 (POLR2A) S1787 Signor 14662762
P24928 (POLR2A) S1864 Signor 14662762
P24928 (POLR2A) S1871 Signor 14662762
P24928 (POLR2A) S1878 Signor 14662762
P24928 (POLR2A) S1892 Signor 14662762
P24928 (POLR2A) S1899 Signor 14662762
P24928 (POLR2A) S1913 Signor 14662762
P24928 (POLR2A) S1920 Signor 14662762
P24928 (POLR2A) S1927 Signor 14662762
P24928 (POLR2A) S1934 Signor 14662762
P24928 (POLR2A) S1944 Signor 14662762
P24928 (POLR2A) S1951 Signor 14662762
P24941 (CDK2) T160 PhosphoSitePlus 12359725
P25098 (GRK2) S670 HPRD   neXtProt   Signor 19651622, 18767875, 10574913, ...10727525, 18088087
P27361-3 (MAPK3) T202 HPRD 18691976, 17389395, 7687743, ...17192257, 19651622, 18669648, 8626767
P27361 (MAPK3) Y204 HPRD   neXtProt   PhosphoSitePlus 19901323, 15580310, 17389395, ...18691976, 1835084, 7687743, 8444886, 19651622, 18669648, 18707149, 20068231, 16497976
P27361 (MAPK3) T207 PhosphoSitePlus   Signor   UniProt 19060905, 26823016
P27708 (CAD) T456 phospho.ELM   PhosphoSitePlus   Signor 14991569, 15890648
P27824 (CANX) S583 PhosphoSitePlus 19815548
P28324 (ELK4) T361 neXtProt 9020136
P28324 (ELK4) T366 neXtProt 9020136
P28324 (ELK4) S381 neXtProt 9020136
P28324 (ELK4) S387 neXtProt 9020136
P28324 (ELK4) T420 neXtProt 9020136
P28324 (ELK4) S425 neXtProt 9020136
P28562 (DUSP1) S296 Signor 16286470
P28562 (DUSP1) S323 Signor 16286470
P28562 (DUSP1) S359 Signor 10617468
P28562 (DUSP1) S364 HPRD   phospho.ELM   Signor 10617468
P28698 (MZF1) S256 neXtProt 12427756
P28698 (MZF1) S274 neXtProt 12427756
P28698 (MZF1) S294 neXtProt 12427756
P29353 (SHC1) S36 neXtProt 15930121
P29590-4 (PML) T28 PhosphoSitePlus 15093545
P29590-4 (PML) S36 PhosphoSitePlus 15093545
P29590-4 (PML) S38 PhosphoSitePlus 15093545
P29590-4 (PML) S40 PhosphoSitePlus 15093545
P29590-4 (PML) S527 PhosphoSitePlus 15093545
P29590-4 (PML) S530 PhosphoSitePlus   Signor 15093545
P30307 (CDC25C) S216 RLIMS-P+ 16582626
P31645 (SLC6A4) T616 PhosphoSitePlus 24450286
P32121 (ARRB2) S14 PhosphoSitePlus 26324936
P32121 (ARRB2) T276 PhosphoSitePlus 26324936
P33076 (CIITA) S280 neXtProt   PhosphoSitePlus   Signor 17095509, 26181363
P33076 (CIITA) S288 PhosphoSitePlus   Signor 18245089
P33981 (TTK) S821 PhosphoSitePlus 18787396
P35228 (NOS2) S745 neXtProt   PhosphoSitePlus   Signor 17804409
P35236-2 (PTPN7) T105 HPRD 18088087, 10206983
P35236-2 (PTPN7) S132 HPRD 10206983
P35568 (IRS1) S616 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9395471, 15001544
P35658 (NUP214) S1710 PhosphoSitePlus 19767751
P35658 (NUP214) S1809 PhosphoSitePlus 19767751
P36956 (SREBF1) S117 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10915800, 20863500, 18669648
P36956-4 (SREBF1) S147 HPRD 10915800, 18669648
P37231 (PPARG) S112 Signor 18596912
P40763 (STAT3) Y705 Signor 14551213, 19723038
P40763-2 (STAT3) S726 HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
P40763 (STAT3) S727 HPRD   RLIMS-P+   Signor 19413330, 18691976, 12763138, ...10446219, 12576423, 10521505, 25584415, 20058876, 11350938, 14551213, 19723038, 18669648, 9872331, 9343414, 20068231, 18491316
P41182 (BCL6) S333 PhosphoSitePlus   Signor 9649500
P41182 (BCL6) S343 PhosphoSitePlus   Signor 9649500
P41212 (ETV6) S213 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15060146
P41212 (ETV6) S257 neXtProt   phospho.ELM   PhosphoSitePlus 15060146
P42224 (STAT1) S727 neXtProt   PhosphoSitePlus 17897103, 14963018
P42229 (STAT5A) S780 phospho.ELM   PhosphoSitePlus   Signor 10194762
P42702 (LIFR) S1044 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7777512
P43364 (MAGEA11) S174 neXtProt   PhosphoSitePlus   Signor 19828458
P43694 (GATA4) S105 RLIMS-P+ 22227582
P46527 (CDKN1B) T187 PhosphoSitePlus   Signor 10931950
P47712 (PLA2G4A) S505 Signor 8381049
P49023-2 (PXN) S83 PhosphoSitePlus 20628053
P49023-2 (PXN) S126 PhosphoSitePlus 20628053
P49023 (PXN) S130 neXtProt   PhosphoSitePlus 16537926, 20628053
P49137 (MAPKAPK2) T222 neXtProt 7592979
P49137 (MAPKAPK2) T334 neXtProt 7592979
P49407-2 (ARRB1) S404 HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
P49407-1 (ARRB1) S412 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 15456867, 18767875, ...19153083, 19651622, 17322306, 10347142, 20068231
P49418 (AMPH) S293 Signor 15262992
P49418 (AMPH) S295 Signor 15262992
P49585 (PCYT1A) S315 Signor 15788406
P49675 (STAR) S233 neXtProt 18197253
P49715 (CEBPA) S21 phospho.ELM   PhosphoSitePlus   Signor 14701740
P49790 (NUP153) S257 PhosphoSitePlus 19767751
P49790 (NUP153) S320 PhosphoSitePlus 19767751
P49790 (NUP153) S334 PhosphoSitePlus 19767751
P49790 (NUP153) S338 PhosphoSitePlus 19767751
P49790 (NUP153) T369 PhosphoSitePlus 19767751
P49790 (NUP153) T388 PhosphoSitePlus   Signor 19767751
P49790 (NUP153) T413 PhosphoSitePlus 19767751
P49790 (NUP153) S516 PhosphoSitePlus 19767751
P49790 (NUP153) S522 PhosphoSitePlus 19767751
P49790 (NUP153) S529 PhosphoSitePlus   Signor 19767751
P49815 (TSC2) S664 PhosphoSitePlus 17671177
P49841 (GSK3B) T43 phospho.ELM   PhosphoSitePlus   Signor 16039586
P50616 (TOB1) S152 PhosphoSitePlus   Signor 12050114
P50616 (TOB1) S154 PhosphoSitePlus   Signor 12050114, 12151396
P50616 (TOB1) S164 PhosphoSitePlus   Signor 12151396, 12050114
P51168 (SCNN1B) T615 neXtProt 11805112
P51170 (SCNN1G) T622 neXtProt 11805112
P51812 (RPS6KA3) S227 Signor 10980595
P51812 (RPS6KA3) T577 phospho.ELM   Signor 10980595
P53004 (BLVRA) S230 PhosphoSitePlus 18463290
P53355 (DAPK1) S734 PhosphoSitePlus 26769850
P53805-4 (RCAN1) S32 HPRD 19413330, 12063245, 19651622, ...20068231
P53805-2 (RCAN1) S112 HPRD 19413330, 12063245, 19651622, ...20068231
P53805 (RCAN1) S167 HPRD   neXtProt 19413330, 12063245, 19651622, ...20068231
P55211 (CASP9) T125 HPRD   phospho.ELM   PhosphoSitePlus   Signor 12792650, 18669648, 18083711
P56270 (MAZ) T72 phospho.ELM   PhosphoSitePlus   Signor 11809795
P61586 (RHOA) S88 PhosphoSitePlus 26816343
P61586 (RHOA) T100 PhosphoSitePlus 26816343
P61978 (HNRNPK) S284 phospho.ELM   PhosphoSitePlus   Signor 26804170, 11259409, 16564677, ...11231586
P61978 (HNRNPK) S353 phospho.ELM   PhosphoSitePlus 11259409
P63000 (RAC1) T108 PhosphoSitePlus 24043306
P68431 (HIST1H3J) S29 neXtProt 11278789
P78347-2 (GTF2I) S627 neXtProt   PhosphoSitePlus 10648599
P78347-2 (GTF2I) S633 neXtProt   PhosphoSitePlus 10648599
P78347 (GTF2I) S668 Signor 10648599
P78347 (GTF2I) S674 Signor 10648599
P78536 (ADAM17) T735 phospho.ELM   PhosphoSitePlus   Signor 12058067, 18187448
P84022 (SMAD3) S204 RLIMS-P+ 24080014
P84243 (H3F3B) S29 Signor 15994958
Q00613-1 (HSF1) S307 HPRD   PhosphoSitePlus   Signor 19413330, 18212344, 19664994, ...19651622, 18669648, 20068231, 20166139, 8940068
Q00975 (CACNA1B) S411 neXtProt 16406008
Q00975 (CACNA1B) S446 neXtProt 16406008
Q01196-8 (RUNX1) S276 PhosphoSitePlus 15475366
Q01196-8 (RUNX1) S293 PhosphoSitePlus 15475366
Q01196-8 (RUNX1) T300 PhosphoSitePlus 15475366
Q01196-8 (RUNX1) S303 PhosphoSitePlus 15475366
Q01196-8 (RUNX1) S462 PhosphoSitePlus 15475366
Q01844 (EWSR1) T79 PhosphoSitePlus   Signor 19076070
Q01860 (POU5F1) S111 PhosphoSitePlus   Signor 23024368
Q01892 (SPIB) T56 HPRD   phospho.ELM   Signor 8632909
Q02447 (SP3) S73 PhosphoSitePlus   Signor 17685427
Q02641 (CACNB1) S161 neXtProt 16406008
Q02641 (CACNB1) S348 neXtProt 16406008
Q02750 (MAP2K1) T286 PhosphoSitePlus 25971971
Q02750 (MAP2K1) T292 neXtProt   PhosphoSitePlus 25971971, 8013650, 14993270
Q02750 (MAP2K1) T386 neXtProt 8013650
Q04637-8 (EIF4G1) S1232 PhosphoSitePlus 23263986
Q05209 (PTPN12) S571 PhosphoSitePlus 21876001
Q05397 (PTK2) S910 RLIMS-P+ 20811717
Q05469-1 (LIPE) T891 HPRD 11581251
Q05682-4 (CALD1) S534 PhosphoSitePlus 26079947
Q05682 (CALD1) S759 PhosphoSitePlus   Signor 11983427, 10514499
Q05682 (CALD1) S789 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10514499, 10751321
Q07812 (BAX) T167 RLIMS-P+ 19182807
Q07820 (MCL1) T92 neXtProt   PhosphoSitePlus 18676833
Q07820 (MCL1) T163 neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 25324174, 18676833, 15241487
Q07866 (KLC1) S460 Signor 21385839
Q07869-1 (PPARA) S12 HPRD   Signor 10187842
Q07869-1 (PPARA) S21 HPRD   Signor 10187842
Q07889 (SOS1) S1132 Signor 8816480
Q07889 (SOS1) S1167 Signor 8816480
Q07889 (SOS1) S1178 Signor 8816480
Q07889 (SOS1) S1193 Signor 8816480
Q08499-2 (PDE4D) S579 PhosphoSitePlus 16973330
Q08499 (PDE4D) S715 Signor 10828059
Q09472 (EP300) S1038 RLIMS-P+ 24530506
Q09472 (EP300) S2039 RLIMS-P+ 24530506
Q12772 (SREBF2) S432 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14988395
Q12772 (SREBF2) S455 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14988395
Q12800 (TFCP2) S291 Signor 19237534
Q12800 (TFCP2) S309 Signor 19237534
Q12929 (EPS8) S625 neXtProt 19564905
Q12929 (EPS8) T629 neXtProt 19564905
Q13153 (PAK1) T292 Signor 14993270
Q13164 (MAPK7) T733 PhosphoSitePlus 25689862
Q13322 (GRB10) S150 phospho.ELM   Signor 15952796
Q13322 (GRB10) S476 phospho.ELM   Signor 15952796
Q13362 (PPP2R5C) S337 Signor 16456541
Q13480-2 (GAB1) T312 HPRD 15379552
Q13480-2 (GAB1) S381 HPRD 15379552
Q13480-2 (GAB1) S454 HPRD 15379552
Q13480-1 (GAB1) T476 HPRD 15379552
Q13480-1 (GAB1) S551 HPRD 15379552
Q13480-1 (GAB1) S567 HPRD 15379552
Q13480-2 (GAB1) S581 HPRD 15379552
Q13480-2 (GAB1) S597 HPRD 15379552
Q13485 (SMAD4) T277 phospho.ELM   Signor 12801888
Q13522 (PPP1R1A) S67 neXtProt 11278334
Q13541 (EIF4EBP1) S65 neXtProt   PhosphoSitePlus 11553333
Q13586 (STIM1) S575 RLIMS-P+ 23687376, 25562429
Q13586 (STIM1) S608 RLIMS-P+ 23687376, 25562429
Q13586 (STIM1) S621 RLIMS-P+ 23687376, 25562429
Q13614 (MTMR2) S58 PhosphoSitePlus 23378027
Q13950 (RUNX2) S24 PhosphoSitePlus 19801668
Q13950 (RUNX2) S28 PhosphoSitePlus 19801668
Q13950 (RUNX2) S43 PhosphoSitePlus 19801668
Q13950 (RUNX2) S275 PhosphoSitePlus 19801668
Q13950 (RUNX2) S294 PhosphoSitePlus   Signor 19801668
Q13950 (RUNX2) S312 PhosphoSitePlus   Signor 19801668
Q13950 (RUNX2) S314 PhosphoSitePlus 19801668
Q13950 (RUNX2) S340 PhosphoSitePlus 19801668
Q13950 (RUNX2) S503 PhosphoSitePlus 19801668
Q14005 (IL16) S845 Signor 14768064
Q14160 (SCRIB) T553 neXtProt 20622900
Q14160 (SCRIB) S1448 neXtProt 20622900
Q14247 (CTTN) S405 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20444238, 21079800, 10537323
Q14247 (CTTN) S418 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20444238, 21079800, 10537323
Q14790 (CASP8) S387 PhosphoSitePlus   Signor 24342355
Q14934 (NFATC4) S676 phospho.ELM   PhosphoSitePlus   Signor 15657420
Q15046 (KARS) S207 neXtProt   PhosphoSitePlus   Signor 19524539
Q15366 (PCBP2) S173 RLIMS-P+ 17475908
Q15366 (PCBP2) S189 RLIMS-P+ 17475908
Q15366 (PCBP2) T213 RLIMS-P+ 17475908
Q15366 (PCBP2) S272 RLIMS-P+ 17475908
Q15596 (NCOA2) S736 PhosphoSitePlus 11301320
Q15648 (MED1) T1032 PhosphoSitePlus   Signor 12356758, 16314496
Q15648 (MED1) T1457 phospho.ELM   PhosphoSitePlus   Signor 12356758, 16314496
Q15672 (TWIST1) S68 neXtProt   PhosphoSitePlus   Signor 21502402
Q15746 (MYLK) S1779 neXtProt   PhosphoSitePlus 15310280, 11964068
Q15788 (NCOA1) T1179 phospho.ELM   PhosphoSitePlus   Signor 12163482
Q15788 (NCOA1) S1185 phospho.ELM   PhosphoSitePlus   Signor 12163482
Q15796 (SMAD2) T8 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19413330, 12193595, 18491316, ...18691976, 10197981, 19651622, 19115199, 20068231, 11027280
Q15796 (SMAD2) T220 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 10197981, 19115199
Q15796 (SMAD2) S245 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 10197981, 19115199
Q15796 (SMAD2) S250 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 10197981, 19115199
Q15796 (SMAD2) S255 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12193595, 10197981, 19115199
Q15831 (STK11) S428 Signor 25846811
Q16204 (CCDC6) S244 HPRD 19413330, 18691976, 14712216, ...17287340, 16964243, 15302935, 19664994, 19664995, 15144186, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
Q16254 (E2F4) S244 PhosphoSitePlus 23919615
Q16254 (E2F4) S384 PhosphoSitePlus 23919615
Q16559 (TAL2) S100 PhosphoSitePlus 8152805
Q16665 (HIF1A) S641 Signor 18519666
Q16665 (HIF1A) S643 Signor 18519666
Q16690 (DUSP5) T321 PhosphoSitePlus 19666109
Q16690 (DUSP5) S346 PhosphoSitePlus 19666109
Q16690 (DUSP5) S376 PhosphoSitePlus 19666109
Q16828 (DUSP6) S159 phospho.ELM   PhosphoSitePlus   Signor 15632084
Q16828 (DUSP6) S174 PhosphoSitePlus 19106095
Q16828 (DUSP6) S197 PhosphoSitePlus   Signor 15632084
Q16828 (DUSP6) S300 PhosphoSitePlus 19106095
Q2M1Z3 (ARHGAP31) T789 neXtProt 16024771
Q86UC2 (RSPH3) T286 PhosphoSitePlus 19684019
Q86UR1 (NOXA1) S282 PhosphoSitePlus   Signor 20230789, 20110267
Q86WB0 (ZC3HC1) S354 neXtProt 22955283
Q86WB0 (ZC3HC1) S359 neXtProt 22955283
Q8IX03 (WWC1) S542 PhosphoSitePlus 24269383
Q8IX03 (WWC1) S548 PhosphoSitePlus   Signor 24269383
Q8IZP0 (ABI1) S183 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) S216 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) S225 PhosphoSitePlus   Signor 21419341
Q8IZP0 (ABI1) T265 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) S267 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) S392 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) T394 PhosphoSitePlus 21419341
Q8IZP0 (ABI1) S410 PhosphoSitePlus 21419341
Q8N122 (RPTOR) S8 neXtProt   PhosphoSitePlus   Signor 21071439
Q8N122 (RPTOR) S696 neXtProt   PhosphoSitePlus   Signor 21071439
Q8N122 (RPTOR) S863 neXtProt   PhosphoSitePlus   Signor 21071439, 19864431
Q8N9N5 (BANP) T337 PhosphoSitePlus 26080397
Q8N9N5 (BANP) T352 PhosphoSitePlus 26080397
Q8WX93 (PALLD) S688 PhosphoSitePlus 22216253
Q8WX93 (PALLD) S808 PhosphoSitePlus 22216253
Q92793 (CREBBP) S93 PhosphoSitePlus 21751375
Q92908 (GATA6) S266 PhosphoSitePlus 18454176
Q92934 (BAD) S75 PhosphoSitePlus 25681438
Q92974-2 (ARHGEF2) T678 PhosphoSitePlus 24043311
Q92974 (ARHGEF2) T679 PhosphoSitePlus   Signor 18211802, 19261619
Q92974-2 (ARHGEF2) S959 PhosphoSitePlus 24043311
Q93045-1 (STMN2) S62 HPRD   neXtProt 9525956, 9126608
Q93045-1 (STMN2) S73 HPRD   neXtProt 9525956, 9126608
Q969H0 (FBXW7) T205 PhosphoSitePlus 25753158
Q969V6 (MRTFA) S454 PhosphoSitePlus   Signor 18694962, 22139079
Q96FF9 (CDCA5) S79 PhosphoSitePlus 20551060
Q96FF9 (CDCA5) S209 PhosphoSitePlus 20551060
Q96Q27 (ASB2) S323 PhosphoSitePlus 24044920
Q96RK0 (CIC) S1389 PhosphoSitePlus 21087211
Q96RK0 (CIC) S1409 PhosphoSitePlus   Signor 21087211
Q9BR01 (SULT4A1) T11 neXtProt   PhosphoSitePlus   Signor 20920535
Q9BUB5 (MKNK1) T385 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155018
Q9BZI1 (IRX2) S317 neXtProt 15133517
Q9H8Y8 (GORASP2) T222 neXtProt   PhosphoSitePlus 11408587
Q9H8Y8 (GORASP2) T225 neXtProt   PhosphoSitePlus 11408587
Q9NQ66 (PLCB1) S982 HPRD   phospho.ELM   PhosphoSitePlus 11287604
Q9NRA0 (SPHK2) S387 neXtProt   PhosphoSitePlus   Signor 17311928
Q9NRA0 (SPHK2) T614 neXtProt   PhosphoSitePlus   Signor 17311928
Q9NRF2 (SH2B1) S96 PhosphoSitePlus 10473609
Q9NYA1 (SPHK1) S225 PhosphoSitePlus   Signor 14532121
Q9NYV6 (RRN3) S633 phospho.ELM   PhosphoSitePlus   Signor 12620228
Q9NYV6 (RRN3) S649 Signor 12620228
Q9UBN7 (HDAC6) T1031 PhosphoSitePlus   Signor 24089523
Q9UBN7 (HDAC6) S1035 PhosphoSitePlus   Signor 24089523
Q9UHB6 (LIMA1) S362 RLIMS-P+ 23188829
Q9UHB6 (LIMA1) S604 RLIMS-P+ 23188829
Q9UIG0 (BAZ1B) S158 PhosphoSitePlus   Signor 19776015
Q9UJY1 (HSPB8) S24 neXtProt   PhosphoSitePlus 21526341
Q9UJY1 (HSPB8) S27 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22721717, 11342557, 18212344, ...21526341
Q9UJY1 (HSPB8) T87 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22721717, 11342557, 20068231, ...21526341
Q9UJY1 (HSPB8) S159 neXtProt 21526341
Q9UKX7 (NUP50) S221 PhosphoSitePlus   Signor 19767751
Q9UKX7 (NUP50) S315 PhosphoSitePlus   Signor 19767751
Q9ULC4 (MCTS1) T81 PhosphoSitePlus 17016429
Q9UPT5 (EXOC7) S250 PhosphoSitePlus 22595671
Q9UQC2 (GAB2) S623 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15356145
Q9Y6W5 (WASF2) S343 PhosphoSitePlus 21419341
Q9Y6W5 (WASF2) T346 PhosphoSitePlus 21419341
Q9Y6W5 (WASF2) S351 PhosphoSitePlus 21419341
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025935 (hSMAD2/iso:Long/Phos:2) pT8,pT220,pS245,pS250,pS255,pS465,pS467 PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048322 (hMAPK3/InitMet-/Phos:1) pT202,pY204 PRO
PR:000026189 (hMAPK3/iso:1/Phos:1) pT202,pY204 PRO 17192257


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 L58 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S159 Y159 Biomuta DOID:1324 / lung cancer [ tcga ]
T198 I198 Biomuta DOID:363 / uterine cancer [ tcga ]
Y204 C204 Biomuta DOID:1324 / lung cancer [ cosmic ]
R211 Q211 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
R211 W211 Biomuta DOID:9256 / colorectal cancer [ tcga ]