Protein Information

Cytoscape View


UniProt AC / UniProt ID P27348 / 1433T_HUMAN
Protein Name 14-3-3 protein theta
Gene Name Name: YWHAQ
Organism Homo sapiens (Human)

PRO ID PR:P27348
DAG View
PRO Name 14-3-3 protein theta (human)
Definition A 14-3-3 protein theta that is encoded in the genome of human.
Short Label hYWHAQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27348 (YWHAQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 25944712
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Ubiquitination PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
C25 S-Nitrosylation dbSNO 2212679, 22126794, 26338901, ...16648260
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S45 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus   UniProt 19608861
K49 Ubiquitination PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
C94 S-Nitrosylation dbSNO 19483679, 25040305
T95 Phosphorylation HPRD 20068231
K103 Ubiquitination PhosphoSitePlus
T110 Phosphorylation HPRD 20068231
S114 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus   UniProt 19608861
K115 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
C134 S-Nitrosylation dbSNO 19483679, 19101475, 20140087
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Methylation PhosphoSitePlus
S214 Phosphorylation HPRD   PhosphoSitePlus 20068231
T215 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 19664995
S232 Phosphorylation P11274 (BCR) , P48729 (CSNK1A1) , P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 17081983, 19664995, ...9360956, 18669648, 16045749, 25862939, 19415658, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14558 (HSPB6) S16 P27348 (YWHAQ) unknown eFIP 33339131
Phosphorylation P04150 (NR3C1) T524 P27348 (YWHAQ) unknown eFIP 33744286
Phosphorylation P04637 (TP53) T387 P27348 (YWHAQ) unknown eFIP 32501690
Phosphorylation P30305 (CDC25B) S323 P27348 (YWHAQ) unknown eFIP 30468767
Phosphorylation P56524 (HDAC4) S246 P27348 (YWHAQ) unknown eFIP 33537682
Phosphorylation P67828 (CSNK1A1) S218 P27348 (YWHAQ) unknown eFIP 19860830
Phosphorylation Q12778 (FOXO1) S256 P27348 (YWHAQ) unknown eFIP 31308176
Phosphorylation Q13094 (LCP2) S376 P27348 (YWHAQ) unknown eFIP 33159816
Phosphorylation Q5S006 (Lrrk2) S935 P27348 (YWHAQ) inhibited_association eFIP 20642453
Phosphorylation Q5S007 (LRRK2) S935 P27348 (YWHAQ) increased_association eFIP 22723946


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) Interaction PR:P27348 (hYWHAQ) PRO 16511560


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K3 N3 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
Y19 C19 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
S37 T37 Biomuta DOID:1319 / brain cancer [ icgc ]
S57 F57 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K74 R74 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S92 Y92 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T110 N110 Biomuta DOID:3571 / liver cancer [ icgc ]
S114 T114 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y125 C125 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T141 A141 Biomuta DOID:3571 / liver cancer [ tcga ]
S156 R156 Biomuta DOID:363 / uterine cancer [ tcga ]
K157 N157 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K193 T193 Biomuta DOID:263 / kidney cancer [ cosmic ]