iPTMnet Report for P27348 (YWHAQ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P27348 / 1433T_HUMAN
Protein Name 14-3-3 protein theta
Gene Name Name: YWHAQ
Organism Homo sapiens (Human)

PRO ID PR:P27348
DAG View
PRO Name 14-3-3 protein theta (human)
Definition A 14-3-3 protein theta that is encoded in the genome of human.
Short Label hYWHAQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P27348 (YWHAQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 25944712
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Ubiquitination PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
C25 Methylation IEDB 31844290
C25 S-Nitrosylation dbSNO 2212679, 22126794, 26338901, ...16648260
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S45 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 32501683, 20068231
Y48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus   UniProt 19608861
K49 Ubiquitination PhosphoSitePlus
S57 O-Glycosylation GlyGen 23301498, 30444036, 35138101, ...30379171, 18369606, 33214551, 34019948, 34931806, 33465208
S57 Phosphorylation PhosphoSitePlus
S63 O-Glycosylation GlyGen 23301498, 30444036, 35138101, ...30379171, 18369606, 33214551, 34019948, 34931806, 33465208
S64 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
T69 O-Glycosylation GlyGen 33465208
T71 O-Glycosylation GlyGen 33465208
S72 O-Glycosylation GlyGen 33465208
K74 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
C94 Methylation IEDB 31844290
C94 S-Nitrosylation dbSNO 19483679, 25040305
T95 Phosphorylation HPRD 20068231
K103 Ubiquitination PhosphoSitePlus
T110 Phosphorylation HPRD 20068231
S114 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus   UniProt 19608861
K115 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
C134 S-Nitrosylation dbSNO 19483679, 19101475, 20140087
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
S156 O-Glycosylation GlyGen 23301498, 30444036, 35138101, ...30379171, 18369606, 33214551, 34019948, 34931806, 33465208
S156 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Methylation PhosphoSitePlus
S214 Phosphorylation HPRD   PhosphoSitePlus 20068231
T215 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 19664995
S232 Phosphorylation P11274 (BCR) , P48729 (CSNK1A1) , P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 17081983, 19664995, ...9360956, 18669648, 16045749, 25862939, 19415658, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14558 (HSPB6) S16 P27348 (YWHAQ) unknown eFIP 33339131
Phosphorylation O43524 (FOXO3) S253 P27348 (YWHAQ) unknown eFIP 35874228
Phosphorylation P00338 (LDHA) S161 P27348 (YWHAQ) increased_association eFIP 36239424
Phosphorylation P04150 (NR3C1) T524 P27348 (YWHAQ) unknown eFIP 33744286
Phosphorylation P56524 (HDAC4) S246 P27348 (YWHAQ) unknown eFIP 33537682
Phosphorylation Q13094 (LCP2) S376 P27348 (YWHAQ) unknown eFIP 33159816
Phosphorylation Q13470 (TNK1) S502 P27348 (YWHAQ) increased_association eFIP 34504101
Phosphorylation Q5S007 (LRRK2) S935 P27348 (YWHAQ) inhibited_association eFIP 20642453
Phosphorylation Q96PU5 (NEDD4L) S448 P27348 (YWHAQ) unknown eFIP 34294877
Phosphorylation Q9NP71 (MLXIPL) S196 P27348 (YWHAQ) unknown eFIP 32776146


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025837 (hMDM4/iso:1/PhosUbiq:1) Interaction PR:P27348 (hYWHAQ) PRO 16511560