iPTMnet Report for P27037 (ACVR2A)
Protein Information
| UniProt AC / UniProt ID | P27037 / AVR2A_HUMAN |
| Protein Name | Activin receptor type-2A precursor |
| Gene Name | Name: ACVR2A Synonyms:ACVR2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P27037 |
| PRO Name | activin receptor type-2A (human) |
| Definition | An activin receptor type-2A that is encoded in the genome of human. |
| Short Label | hACVR2A |
| Category | organism-gene |
DAG ViewP27037 (ACVR2A) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y215 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K254 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K315 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K326 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K351 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T486 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y233 | * | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
| K315 | N315 | Biomuta | DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] | |
| K351 | E351 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T486 | A486 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
