Protein Information

Cytoscape View


UniProt AC / UniProt ID P26640 / SYVC_HUMAN
Protein Name Valine--tRNA ligase
Gene Name Name: VARS
Synonyms:G7A,VARS2;
Organism Homo sapiens (Human)

PRO ID PR:P26640
DAG View
PRO Name valine--tRNA ligase (human)
Definition A valine--tRNA ligase that is encoded in the genome of human.
Short Label hVARS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26640 (VARS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 22223895
C41 S-Nitrosylation dbSNO 26338901
S124 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S301 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K423 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus   UniProt 23186163
K450 Ubiquitination PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus   UniProt 23186163
K552 Ubiquitination PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
Y601 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K645 Acetylation PhosphoSitePlus   UniProt 19608861
K645 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
R699 Methylation PhosphoSitePlus
Y734 Phosphorylation PhosphoSitePlus
T737 Phosphorylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
Y878 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
Y929 Phosphorylation PhosphoSitePlus
K952 Acetylation PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
K966 Ubiquitination PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1120 Phosphorylation PhosphoSitePlus
Y1125 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1230 Ubiquitination PhosphoSitePlus
K1242 Ubiquitination PhosphoSitePlus
K1252 Ubiquitination PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622
Y5 Phosphorylation HPRD 19651622
S15 Phosphorylation HPRD 19651622
Y300 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:363 / uterine cancer [ tcga ]
T279 I279 Biomuta DOID:3070 / malignant glioma [ tcga ]
K289 N289 Biomuta DOID:1909 / melanoma [ tcga ]
K450 T450 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y469 H469 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y601 C601 Biomuta DOID:3571 / liver cancer [ tcga ]
S1120 F1120 Biomuta DOID:1909 / melanoma [ tcga ]