iPTMnet Report for P26639 (TARS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P26639 / SYTC_HUMAN
Protein Name Threonine--tRNA ligase 1, cytoplasmic
Gene Name Name: TARS1
Synonyms:TARS;
Organism Homo sapiens (Human)

PRO ID PR:P26639
DAG View
PRO Name threonine--tRNA ligase 1, cytoplasmic (human)
Definition A threonine--tRNA ligase 1, cytoplasmic that is encoded in the genome of human.
Short Label hTARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26639 (TARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
K18 Sumoylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y53 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
C107 S-Nitrosylation dbSNO 19483679
S110 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
C137 Methylation IEDB 31844290
S200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
C206 Methylation IEDB 31844290
K213 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K243 Acetylation PhosphoSitePlus   UniProt 19608861
K243 Ubiquitination PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus   UniProt 23186163
R262 Methylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163
S301 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
C343 Methylation IEDB 31844290
R367 Methylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
R433 Methylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus   UniProt 23186163
K504 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K529 Acetylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
K584 Acetylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
K660 Acetylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus   UniProt 23186163
K712 Acetylation PhosphoSitePlus
K712 Sumoylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 20068231
Y353 Phosphorylation HPRD 18083107
S499 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K5 N5 Biomuta DOID:363 / uterine cancer [ icgc ]
S10 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S39 C39 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y53 N53 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y55 H55 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K65 Q65 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K84 Q84 Biomuta DOID:3571 / liver cancer [ cosmic ]
R262 Q262 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R262 W262 Biomuta DOID:184 / bone cancer [ cosmic ]
K279 I279 Biomuta DOID:3571 / liver cancer [ cosmic ]
K279 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S281 Y281 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S281 F281 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S281 P281 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y298 H298 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K313 R313 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K319 T319 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S339 G339 Biomuta DOID:4159 / skin cancer [ cosmic ]
R367 K367 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R367 I367 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R433 W433 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S446 Y446 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T453 I453 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y575 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K583 E583 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K636 R636 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K681 E681 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S702 F702 Biomuta DOID:5041 / esophageal cancer [ cosmic ]