iPTMnet Report for P26599 (PTBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P26599 / PTBP1_HUMAN
Protein Name Polypyrimidine tract-binding protein 1
Gene Name Name: PTBP1
Synonyms:PTB;
Organism Homo sapiens (Human)

PRO ID PR:P26599
DAG View
PRO Name polypyrimidine tract-binding protein 1 (human)
Definition A polypyrimidine tract-binding protein 1 that is encoded in the genome of human.
Short Label hPTBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26599 (PTBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
S16 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23208419, 18669648, 25545659, ...23186163, 12851456
S16 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 12851456
T25 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 23584533, 35132862, 35083852, 22967762, 32119511
S35 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
S53 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
T103 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
T109 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
Y127 Phosphorylation phospho.ELM   UniProt 18083107, 23186163, 16497976
T138 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
T138 Phosphorylation UniProt 20068231
S140 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
S141 Phosphorylation phospho.ELM   UniProt 18669648, 21406692, 23186163, ...17081983, 20068231
C250 S-Nitrosylation dbSNO 19483679, 26338901
C251 S-Nitrosylation dbSNO 19483679, 26338901
T292 O-Glycosylation GlyGen 23301498, 33214551, 30397120, ...30379171, 20305658, 34725712, 34019948, 25367160, 29351928, 35132862, 35083852, 22967762, 32119511
S459 Phosphorylation UniProt 21406692, 23186163, 17924679
Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
K13 Sumoylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation HPRD   PhosphoSitePlus 12851456, 18669648
S16 Phosphorylation P17612 (PRKACA) HPRD 12851456, 18669648
S21 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
T25 O-Glycosylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S35 Phosphorylation HPRD   PhosphoSitePlus 18452278
S37 Phosphorylation HPRD   PhosphoSitePlus 18452278
K45 Acetylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Sumoylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K84 Sumoylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation HPRD   PhosphoSitePlus 18083107
S131 Phosphorylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T138 Phosphorylation HPRD   PhosphoSitePlus 20068231
S140 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17081983, 19651622, ...19415658, 20068231
S141 Phosphorylation HPRD   PhosphoSitePlus 17081983, 19651622, 18669648, ...19415658, 20068231, 17924679
S159 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K218 Sumoylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Sumoylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K266 Acetylation PhosphoSitePlus
K266 Sumoylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
T427 Phosphorylation HPRD   PhosphoSitePlus 20068231
K428 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S433 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231, 17924679
S443 Phosphorylation HPRD   PhosphoSitePlus 20068231
S466 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K485 Acetylation PhosphoSitePlus
K485 Sumoylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K528 Acetylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
T530 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 12851456, 18669648
S16 Phosphorylation P17612 (PRKACA) HPRD 12851456, 18669648
S35 Phosphorylation HPRD 18452278
S37 Phosphorylation HPRD 18452278
Y127 Phosphorylation HPRD 18083107
T138 Phosphorylation HPRD 20068231
S140 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231, 19415658
S141 Phosphorylation HPRD 17081983, 19651622, 18669648, ...19415658, 20068231, 17924679
T446 Phosphorylation HPRD 20068231
S452 Phosphorylation HPRD 18691976, 20068231, 17924679
S462 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 12851456, 18669648
S16 Phosphorylation P17612 (PRKACA) HPRD 12851456, 18669648
S35 Phosphorylation HPRD 18452278
S37 Phosphorylation HPRD 18452278
Y127 Phosphorylation HPRD 18083107
T138 Phosphorylation HPRD 20068231
S140 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231, 19415658
S141 Phosphorylation HPRD 17081983, 19651622, 18669648, ...19415658, 20068231, 17924679
T453 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 18691976, 20068231, 17924679
S469 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 F16 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S21 Y21 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S35 L35 Biomuta DOID:363 / uterine cancer [ icgc ]
K45 N45 Biomuta DOID:1319 / brain cancer [ cosmic ]
S51 R51 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R52 Q52 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
R52 G52 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S131 Y131 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K134 E134 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T138 I138 Biomuta DOID:4159 / skin cancer [ cosmic ]
S140 G140 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S167 L167 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
C250 F250 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
S272 R272 Biomuta DOID:4159 / skin cancer [ cosmic ]
K368 N368 Biomuta DOID:363 / uterine cancer [ icgc ]
K402 E402 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S433 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S452 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S459 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]