iPTMnet Report for P26583 (HMGB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P26583 / HMGB2_HUMAN
Protein Name High mobility group protein B2
Gene Name Name: HMGB2
Synonyms:HMG2;
Organism Homo sapiens (Human)

PRO ID PR:P26583
DAG View
PRO Name high mobility group protein B2 (human)
Definition A high mobility group protein B2 that is encoded in the genome of human.
Short Label hHMGB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26583 (HMGB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
R24 Methylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus   UniProt 19608861
K30 Ubiquitination PhosphoSitePlus
S35 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14729942, 23186163, 17287340
S42 Phosphorylation HPRD   PhosphoSitePlus 20068231
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
C106 Methylation IEDB 31844290
S107 Phosphorylation PhosphoSitePlus
R110 Methylation PhosphoSitePlus
K112 Methylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S134 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S137 Phosphorylation HPRD   PhosphoSitePlus 20068231
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
Y155 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S168 Phosphorylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K182 Acetylation PhosphoSitePlus
K183 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R10 W10 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K12 N12 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S42 C42 Biomuta DOID:1324 / lung cancer [ cosmic ]
K59 T59 Biomuta DOID:363 / uterine cancer [ icgc ]
C106 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S107 A107 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K128 R128 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K141 E141 Biomuta DOID:363 / uterine cancer [ icgc ]
Y155 C155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S168 I168 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]