iPTMnet Report for P26368 (U2AF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P26368 / U2AF2_HUMAN
Protein Name Splicing factor U2AF 65 kDa subunit
Gene Name Name: U2AF2
Synonyms:U2AF65;
Organism Homo sapiens (Human)

PRO ID PR:P26368
DAG View
PRO Name splicing factor U2AF 65 kDa subunit (human)
Definition A splicing factor U2AF 65 kDa subunit that is encoded in the genome of human.
Short Label hU2AF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26368 (U2AF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895, ...20068231
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...16097034, 20068231
K15 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S53 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S55 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S62 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R67 Methylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus   UniProt 19608861
K70 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 18220336, ...18234856, 18669648, 24275569, 23186163, 20068231
S79 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
T124 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
K195 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus   UniProt 23186163
C379 Methylation IEDB 31844290
C406 Methylation IEDB 31844290
K413 Ubiquitination PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
C429 Methylation IEDB 31844290
K431 Ubiquitination PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
R457 Methylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
C464 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 19651622, 18578522, ...17081983, 20068231
S53 Phosphorylation HPRD 17081983, 20068231
S55 Phosphorylation HPRD 17081983, 20068231
S62 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 17322306, 17287340, 18767875, ...18452278, 19651622, 18669648, 20166139, 17924679, 20068231, 20068230
T124 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19413330, 19651622, 18578522, ...17081983, 20068231
S53 Phosphorylation HPRD 17081983, 20068231
S55 Phosphorylation HPRD 17081983, 20068231
S62 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 17322306, 17287340, 18767875, ...18452278, 19651622, 18669648, 20166139, 17924679, 20068231, 20068230
T124 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 F79 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
T124 N124 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T124 S124 Biomuta DOID:1324 / lung cancer [ cosmic ]
K195 N195 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K195 R195 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S257 C257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y269 H269 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S281 F281 Biomuta DOID:4159 / skin cancer [ cosmic ]
K413 R413 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]