Protein Information

Cytoscape View


UniProt AC / UniProt ID P26358 / DNMT1_HUMAN
Protein Name DNA (cytosine-5)-methyltransferase 1
Gene Name Name: DNMT1
Synonyms:AIM,CXXC9,DNMT;
Organism Homo sapiens (Human)

PRO ID PR:P26358
DAG View
PRO Name DNA (cytosine-5)-methyltransferase 1 (human)
Definition A DNA (cytosine-5)-methyltransferase 1 that is encoded in the genome of human.
Short Label hDNMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26358 (DNMT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K70 Methylation PhosphoSitePlus   UniProt 18438403
K70 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S127 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...20613874, 18669648, 19690332
S133 Phosphorylation PhosphoSitePlus   UniProt 21406692
K134 Ubiquitination PhosphoSitePlus
T137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S141 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K142 Methylation PhosphoSitePlus   UniProt 21151116
S143 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 18669648, 21151116, ...20613874, 26553800
K148 Sumoylation PhosphoSitePlus
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 28869544
S154 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26815200, 17287340, 18669648, ...23186163, 21565170
K160 Acetylation PhosphoSitePlus   UniProt 21947282
T165 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus   UniProt 23186163
T168 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus   UniProt 19608861
K173 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus   UniProt 21947282
S189 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K194 Sumoylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus   UniProt 21947282
K259 Sumoylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 23186163
T328 Phosphorylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus   UniProt 21947282
K385 Ubiquitination PhosphoSitePlus
S394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S398 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y399 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus   UniProt 23186163
K586 Ubiquitination PhosphoSitePlus
T591 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K675 Sumoylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
S714 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 21659604, 20068231
K716 Ubiquitination PhosphoSitePlus
S732 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
K739 Sumoylation PhosphoSitePlus
K749 Acetylation PhosphoSitePlus   UniProt 21947282
S878 Phosphorylation PhosphoSitePlus   UniProt 23186163
K881 Ubiquitination PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
K891 Acetylation PhosphoSitePlus   UniProt 21947282
S919 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
S954 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K957 Acetylation PhosphoSitePlus   UniProt 21947282
K957 Sumoylation PhosphoSitePlus
K957 Ubiquitination PhosphoSitePlus
K961 Acetylation PhosphoSitePlus   UniProt 21947282
K961 Ubiquitination PhosphoSitePlus
Y969 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K975 Acetylation PhosphoSitePlus   UniProt 21947282
K975 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
K981 Methylation PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1020 Ubiquitination PhosphoSitePlus
K1054 Acetylation PhosphoSitePlus   UniProt 21947282
K1092 Ubiquitination PhosphoSitePlus
K1094 Ubiquitination PhosphoSitePlus
S1105 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K1111 Acetylation PhosphoSitePlus   UniProt 19608861, 21947282
K1113 Acetylation PhosphoSitePlus   UniProt 19608861, 21947282
K1115 Acetylation PhosphoSitePlus   UniProt 19608861, 21947282
K1117 Acetylation PhosphoSitePlus   UniProt 21947282
K1119 Acetylation PhosphoSitePlus
K1121 Acetylation PhosphoSitePlus
S1122 Phosphorylation PhosphoSitePlus
K1135 Sumoylation PhosphoSitePlus
K1135 Ubiquitination PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
T1204 Phosphorylation PhosphoSitePlus
K1214 Ubiquitination PhosphoSitePlus
Y1254 Phosphorylation PhosphoSitePlus
K1323 Ubiquitination PhosphoSitePlus
K1349 Acetylation PhosphoSitePlus   UniProt 21947282
K1349 Ubiquitination PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus
R1401 Methylation PhosphoSitePlus
Y1405 Phosphorylation PhosphoSitePlus
K1415 Acetylation PhosphoSitePlus   UniProt 21947282
K1415 Ubiquitination PhosphoSitePlus
S1447 Phosphorylation PhosphoSitePlus
Y1457 Phosphorylation PhosphoSitePlus
T1458 Phosphorylation PhosphoSitePlus
R1473 Methylation PhosphoSitePlus
K1483 Ubiquitination PhosphoSitePlus
S1524 Phosphorylation PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
T1526 Phosphorylation PhosphoSitePlus
K1535 Ubiquitination PhosphoSitePlus
K1572 Ubiquitination PhosphoSitePlus
K1586 Ubiquitination PhosphoSitePlus
K1599 Ubiquitination PhosphoSitePlus
S1605 Phosphorylation PhosphoSitePlus
K1609 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S127 Phosphorylation PR:000029189 (AKT kinase) , PR:000003057 (conventional protein kinase C) HPRD   PRO 19651622, 18669648, 20613874, ...18452278
S133 Phosphorylation HPRD 19651622
T137 Phosphorylation HPRD 18669648
S141 Phosphorylation HPRD 18669648
S143 Phosphorylation PR:000029189 (AKT kinase) HPRD   PRO 18669648, 20613874, 18452278
S152 Phosphorylation HPRD 18669648, 20068231
S154 Phosphorylation HPRD 18669648, 17287340, 20068231
T208 Phosphorylation HPRD 20068231
S209 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231
S346 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 18669648, 20068231
S398 Phosphorylation HPRD 20068231
S714 Phosphorylation HPRD 19413330, 20230923, 19664994, ...15302935, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
S954 Phosphorylation HPRD 15302935, 20068231
Y969 Phosphorylation HPRD 18083107
S1105 Phosphorylation HPRD 18767875, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K142 Methylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037505 (hDNMT1/Phos:1) pS127 PR:000003057 (conventional protein kinase C) PRO 20613874
PR:000037505 (hDNMT1/Phos:1) pS127 PR:000029189 (AKT kinase) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) pS127 PR:000003057 (conventional protein kinase C) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) pS127,pS143 PR:000029189 (AKT kinase) PRO 20613874


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P26358 (DNMT1) S127 Q96T88 (UHRF1) decreased_association eFIP 20613874
Phosphorylation P26358 (DNMT1) S127 P12004 (PCNA) decreased_association eFIP 20613874


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037504 (hDNMT1/UnPhos:1) Interaction PR:Q96T88 (hUHRF1) PRO 20613874
PR:000037504 (hDNMT1/UnPhos:1) Interaction PR:P12004 (hPCNA) PRO 20613874
PR:000037505 (hDNMT1/Phos:1) decreased Interaction PR:P12004 (hPCNA) PRO 20613874
PR:000037505 (hDNMT1/Phos:1) decreased Interaction PR:Q96T88 (hUHRF1) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) decreased Interaction PR:P12004 (hPCNA) PRO 20613874
PR:000037506 (hDNMT1/Phos:2) decreased Interaction PR:Q96T88 (hUHRF1) PRO 20613874


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K45 Q45 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S84 C84 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T165 I165 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T166 I166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K173 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K188 T188 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S189 L189 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S227 A227 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S312 F312 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S977 F977 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K981 N981 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S983 R983 Biomuta DOID:3571 / liver cancer [ icgc ]
S1122 C1122 Biomuta DOID:1612 / breast cancer [ icgc ]
S1447 L1447 Biomuta DOID:1612 / breast cancer [ tcga ]
R1473 S1473 Biomuta DOID:3571 / liver cancer [ icgc ]
R1473 C1473 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1524 G1524 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]