iPTMnet Report for P26196 (DDX6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P26196 / DDX6_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX6
Gene Name Name: DDX6
Synonyms:HLR2,RCK;
Organism Homo sapiens (Human)

PRO ID PR:P26196
DAG View
PRO Name probable ATP-dependent RNA helicase DDX6 (human)
Definition A probable ATP-dependent RNA helicase DDX6 that is encoded in the genome of human.
Short Label hDDX6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P26196 (DDX6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
T36 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
T38 Phosphorylation PhosphoSitePlus
N52 N-Glycosylation GlyGen 24190977
T64 Phosphorylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
S181 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...30379171, 34725712, 21740066, 35254053, 34019948, 22967762, 29351928
K195 Ubiquitination PhosphoSitePlus
T199 Phosphorylation HPRD   PhosphoSitePlus 20068230
K231 Ubiquitination PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
C324 Methylation IEDB 31844290
C324 S-Nitrosylation dbSNO 19483679
T327 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...30379171, 34725712, 21740066, 35254053, 34019948, 22967762, 29351928
T327 Phosphorylation PhosphoSitePlus
S330 O-Glycosylation GlyGen 33214551, 28510447, 35138101, ...30379171, 34725712, 21740066, 35254053, 34019948, 22967762, 29351928
S330 Phosphorylation PhosphoSitePlus
R375 Methylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
Y473 Phosphorylation HPRD   PhosphoSitePlus 19901323
S475 Phosphorylation HPRD   PhosphoSitePlus 19901323
K482 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T38 K38 Biomuta DOID:3571 / liver cancer [ cosmic ]
K74 E74 Biomuta DOID:4362 / cervical cancer [ icgc ]
K81 N81 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T199 S199 Biomuta DOID:1324 / lung cancer [ cosmic ]
S330 F330 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S330 T330 Biomuta DOID:263 / kidney cancer [ cosmic ]
R375 H375 Biomuta DOID:363 / uterine cancer [ icgc ]
R375 C375 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K466 N466 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K482 E482 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]