iPTMnet Report P25705 ATP5F1A

Protein Information

UniProt AC / UniProt ID	P25705 / ATPA_HUMAN
Protein Name	ATP synthase subunit alpha, mitochondrial precursor
Gene Name	Name: ATP5F1A Synonyms:ATP5A,ATP5A1;
Organism	Homo sapiens (Human)

PRO ID	PR:P25705 DAG View
PRO Name	ATP synthase subunit alpha, mitochondrial (human)
Definition	An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of human.
Short Label	hATP5F1A
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P25705 (ATP5F1A) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
K45	Ubiquitination	score1	PhosphoSitePlus
T46	O-Glycosylation	score3	GlyGen	23271734, 26358770, 30444036, ...30397120, 26374642, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020, 20068230
T48	O-Glycosylation	score3	GlyGen	23271734, 26358770, 30444036, ...30397120, 26374642, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020, 20068230
T48	Phosphorylation	score1	PhosphoSitePlus
S53	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
T64	Phosphorylation	score1	PhosphoSitePlus
S65	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
S76	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163, 24275569
R88	Methylation	score1	PhosphoSitePlus
S99	Phosphorylation	score1	PhosphoSitePlus
S100	Phosphorylation	score1	PhosphoSitePlus
K123	Acetylation	score1	PhosphoSitePlus
K126	Ubiquitination	score1	PhosphoSitePlus
K132	Acetylation	score1	PhosphoSitePlus
T134	Phosphorylation	score1	PhosphoSitePlus
K161	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K161	Ubiquitination	score1	PhosphoSitePlus
S166	Phosphorylation	score2	PhosphoSitePlus UniProt	21406692, 23186163
K167	Ubiquitination	score1	PhosphoSitePlus
K175	Ubiquitination	score1	PhosphoSitePlus
S184	Phosphorylation	score2	PhosphoSitePlus UniProt	23186163
K194	Ubiquitination	score1	PhosphoSitePlus
S198	Phosphorylation	score1	PhosphoSitePlus
R204	Methylation	score1	PhosphoSitePlus
R207	Methylation	score1	PhosphoSitePlus
R214	Methylation	score1	PhosphoSitePlus
K218	Ubiquitination	score1	PhosphoSitePlus
S220	Phosphorylation	score1	PhosphoSitePlus
T225	O-Glycosylation	score3	GlyGen	23271734, 26358770, 30444036, ...30397120, 26374642, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020, 20068230
T225	Phosphorylation	score1	PhosphoSitePlus
K230	Acetylation	score1	PhosphoSitePlus
K230	Ubiquitination	score1	PhosphoSitePlus
K239	Acetylation	score1	PhosphoSitePlus
K240	Acetylation	score1	PhosphoSitePlus
K241	Acetylation	score1	PhosphoSitePlus
Y243	Phosphorylation	score1	PhosphoSitePlus
C244	S-Nitrosylation	score0	dbSNO	24105792
Y246	Phosphorylation	score1	PhosphoSitePlus
S254	Phosphorylation	score1	PhosphoSitePlus
T255	Phosphorylation	score1	PhosphoSitePlus
K261	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K261	Ubiquitination	score1	PhosphoSitePlus
T264	Phosphorylation	score1	PhosphoSitePlus
K270	Acetylation	score1	PhosphoSitePlus
Y299	Phosphorylation	score1	PhosphoSitePlus
K305	Acetylation	score1	PhosphoSitePlus
K305	Ubiquitination	score1	PhosphoSitePlus
Y311	Phosphorylation	score1	PhosphoSitePlus
K316	Ubiquitination	score1	PhosphoSitePlus
Y337	Phosphorylation	score1	PhosphoSitePlus
Y343	Phosphorylation	score1	PhosphoSitePlus
T383	O-Glycosylation	score3	GlyGen	23271734, 26358770, 30444036, ...30397120, 26374642, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020, 20068230
T389	O-Glycosylation	score1	GlyGen	29351928
S419	Phosphorylation	score1	PhosphoSitePlus
K427	Acetylation	score1	PhosphoSitePlus
K427	Ubiquitination	score1	PhosphoSitePlus
T432	O-Glycosylation	score3	GlyGen	23271734, 26358770, 30444036, ...30397120, 26374642, 34725712, 26853435, 33214551, 29351928, 34019948, 35083852, 32119511, 30620550, 22121020, 20068230
T432	Phosphorylation	score1	PhosphoSitePlus
K434	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K434	Ubiquitination	score1	PhosphoSitePlus
Y440	Phosphorylation	score1	PhosphoSitePlus
S451	Phosphorylation	score1	PhosphoSitePlus
S462	Phosphorylation	score1	PhosphoSitePlus
S477	Phosphorylation	score1	PhosphoSitePlus
K498	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K498	Ubiquitination	score1	PhosphoSitePlus
S502	Phosphorylation	score1	PhosphoSitePlus
K506	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K506	Ubiquitination	score1	PhosphoSitePlus
K531	Acetylation	score1	PhosphoSitePlus
K531	Ubiquitination	score1	PhosphoSitePlus
K539	Acetylation	score2	PhosphoSitePlus UniProt	19608861
K539	Ubiquitination	score1	PhosphoSitePlus
K541	Ubiquitination	score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
T46	Phosphorylation	score0	HPRD	18452278
S52	Phosphorylation	score0	HPRD	18452278
S53	Phosphorylation	score0	HPRD	18452278
T64	Phosphorylation	score0	HPRD	20068231
S65	Phosphorylation	score0	HPRD	20068231
T71	Phosphorylation	score0	HPRD	20068231
S76	Phosphorylation	score0	HPRD	20068231
T191	Phosphorylation	score0	HPRD	20068231
T219	Phosphorylation	score0	HPRD	20068231
T225	Phosphorylation	score0	HPRD	20068231
S413	Phosphorylation	score0	HPRD	20068231
S419	Phosphorylation	score0	HPRD	20068231
T432	Phosphorylation	score0	HPRD	20068231

Site	PTM Type	Score	Source	PMID
T141	Phosphorylation	score0	HPRD	20068231
T169	Phosphorylation	score0	HPRD	20068231
T175	Phosphorylation	score0	HPRD	20068231
S363	Phosphorylation	score0	HPRD	20068231
S369	Phosphorylation	score0	HPRD	20068231
T382	Phosphorylation	score0	HPRD	20068231

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T46	N46	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S52	P52	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S65	F65	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S99	P99	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K123	E123	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T134	A134	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S184	L184	Biomuta	DOID:4159 / skin cancer [ cosmic ]
R204	H204	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
R214	L214	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R214	*	Biomuta	DOID:363 / uterine cancer [ cosmic ]
Y311	C311	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
K316	N316	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
K316	E316	Biomuta	DOID:1319 / brain cancer [ cosmic ]
K316	R316	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S451	C451	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S502	G502	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P25705 (ATP5F1A)

Protein Information

Interactive Sequence View

P25705 (ATP5F1A) as Substrate

PTM sites affected in variants