Protein Information

Cytoscape View


UniProt AC / UniProt ID P25705 / ATPA_HUMAN
Protein Name ATP synthase subunit alpha, mitochondrial precursor
Gene Name Name: ATP5F1A
Synonyms:ATP5A,ATP5A1;
Organism Homo sapiens (Human)

PRO ID PR:P25705
DAG View
PRO Name ATP synthase subunit alpha, mitochondrial (human)
Definition An ATP synthase subunit alpha, mitochondrial that is encoded in the genome of human.
Short Label hATP5F1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25705 (ATP5F1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
T46 O-Glycosylation GlyGen 23271734, 26358770, 30397120, ...26374642, 26853435, 30444036, 29351928, 32119511, 22121020, 20068230
T48 O-Glycosylation GlyGen 23271734, 26358770, 30397120, ...26374642, 26853435, 30444036, 29351928, 32119511, 22121020, 20068230
T48 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus   UniProt 23186163
T64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   UniProt 23186163
S76 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R88 Methylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus   UniProt 19608861
K161 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K167 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus   UniProt 23186163
K194 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
R204 Methylation PhosphoSitePlus
R207 Methylation PhosphoSitePlus
R214 Methylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
C244 S-Nitrosylation dbSNO 24105792
Y246 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
K261 Acetylation PhosphoSitePlus   UniProt 19608861
K261 Ubiquitination PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
K305 Acetylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
Y337 Phosphorylation PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
T383 O-Glycosylation GlyGen 23271734, 26358770, 30397120, ...26374642, 26853435, 30444036, 29351928, 32119511, 22121020, 20068230
S419 Phosphorylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
T432 O-Glycosylation GlyGen 23271734, 26358770, 30397120, ...26374642, 26853435, 30444036, 29351928, 32119511, 22121020, 20068230
T432 Phosphorylation PhosphoSitePlus
K434 Acetylation PhosphoSitePlus   UniProt 19608861
K434 Ubiquitination PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K498 Acetylation PhosphoSitePlus   UniProt 19608861
K498 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K506 Acetylation PhosphoSitePlus   UniProt 19608861
K506 Ubiquitination PhosphoSitePlus
K531 Acetylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K539 Acetylation PhosphoSitePlus   UniProt 19608861
K539 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T46 Phosphorylation HPRD 18452278
S52 Phosphorylation HPRD 18452278
S53 Phosphorylation HPRD 18452278
T64 Phosphorylation HPRD 20068231
S65 Phosphorylation HPRD 20068231
T71 Phosphorylation HPRD 20068231
S76 Phosphorylation HPRD 20068231
T191 Phosphorylation HPRD 20068231
T219 Phosphorylation HPRD 20068231
T225 Phosphorylation HPRD 20068231
S413 Phosphorylation HPRD 20068231
S419 Phosphorylation HPRD 20068231
T432 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T141 Phosphorylation HPRD 20068231
T169 Phosphorylation HPRD 20068231
T175 Phosphorylation HPRD 20068231
S363 Phosphorylation HPRD 20068231
S369 Phosphorylation HPRD 20068231
T382 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T46 N46 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ]
S52 P52 Biomuta DOID:1909 / melanoma [ cosmic ]
S65 F65 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S99 P99 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T134 A134 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R207 S207 Biomuta DOID:3571 / liver cancer [ tcga ]
R214 * Biomuta DOID:363 / uterine cancer [ tcga ]
Y311 C311 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K316 E316 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K316 R316 Biomuta DOID:3571 / liver cancer [ tcga ]
S451 C451 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S477 Y477 Biomuta DOID:1115 / sarcoma [ tcga ]
S502 G502 Biomuta DOID:1324 / lung cancer [ tcga ]