Protein Information

Cytoscape View

UniProt AC / UniProt ID P25490 / TYY1_HUMAN
Protein Name Transcriptional repressor protein YY1
Gene Name Name: YY1
Organism Homo sapiens (Human)

PRO ID PR:P25490
DAG View
PRO Name transcriptional repressor protein YY1 (human)
Definition A transcriptional repressor protein YY1 that is encoded in the genome of human.
Short Label hYY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P25490 (YY1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation P07948 (LYN) PhosphoSitePlus 26198631
T39 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor 23226345, 21253604
S118 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 23226345, ...22184066, 19691289, 18452278, 19651622, 24275569, 19007248, 16565220, 19690332, 20068231
S165 Phosphorylation PhosphoSitePlus
R171 Methylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
S180 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   RLIMS-P   Signor 23226345
K183 Methylation PhosphoSitePlus
K183 Sumoylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S184 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 23226345, 17287340
Y185 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus   UniProt 23186163
K203 Acetylation PhosphoSitePlus
K203 Sumoylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S247 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 15302935, ...16565220, 18669648, 24275569, 18452278, 19690332, 20068231
Y251 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y254 Phosphorylation P07948 (LYN) PhosphoSitePlus 26198631
K258 Acetylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K286 Sumoylation PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K301 Methylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K305 Methylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
R308 Methylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K315 Methylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
K339 Sumoylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T348 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 17924679
K351 Acetylation PhosphoSitePlus
K351 Sumoylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K362 Methylation PhosphoSitePlus
S365 Phosphorylation HPRD   PhosphoSitePlus 20068231
T378 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
R381 Methylation PhosphoSitePlus
Y383 Phosphorylation P07948 (LYN) PhosphoSitePlus   RLIMS-P 26198631
K393 Sumoylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S247 L247 Biomuta DOID:10534 / stomach cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ]
S247 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K393 R393 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K409 E409 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]