Protein Information

Cytoscape View


UniProt AC / UniProt ID P25445 / TNR6_HUMAN
Protein Name Tumor necrosis factor receptor superfamily member 6 precursor
Gene Name Name: FAS
Synonyms:APT1,FAS1,TNFRSF6;
Organism Homo sapiens (Human)

PRO ID PR:P25445
DAG View
PRO Name tumor necrosis factor receptor superfamily member 6 (human)
Definition A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of human.
Short Label hFAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25445 (FAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T28 O-Glycosylation UniProt 22171320
K33 Ubiquitination PhosphoSitePlus
T40 O-Glycosylation PhosphoSitePlus
T42 O-Glycosylation PhosphoSitePlus
T43 O-Glycosylation PhosphoSitePlus
T46 O-Glycosylation PhosphoSitePlus
Y91 Phosphorylation phospho.ELM   PhosphoSitePlus 17195092, 15660394
N118 N-Glycosylation UniProt 19159218
K204 Ubiquitination PhosphoSitePlus
S209 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S212 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T214 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T219 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S225 Phosphorylation PhosphoSitePlus   UniProt 24275569
S230 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17195092, 15660394, 20682655
T234 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17195092, 15660394, 20682655
T293 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S209 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S212 Phosphorylation HPRD 18669648, 20068231
T214 Phosphorylation HPRD 18669648
T219 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K170 Acetylation PhosphoSitePlus
S188 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S191 Phosphorylation HPRD 18669648, 20068231
T193 Phosphorylation HPRD 18669648
T198 Phosphorylation HPRD 18669648


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036782 (hFASLG/iso:FasL/var:F273L) altered Interaction PR:P25445 (hFAS) PRO 9405425
PR:000036782 (hFASLG/iso:FasL/var:F273L) altered Interaction PR:P25445 (hFAS) PRO 9405425
PR:000036782 (hFASLG/iso:FasL/var:F273L) altered Interaction PR:P25445 (hFAS) PRO 9405425
PR:P25445-1 (hFAS/iso:1) Interaction PR:P15311 (hEZR) PRO 14739941
PR:P25445-1 (hFAS/iso:1) Interaction PR:P15311 (hEZR) PRO 14739941
PR:P25445-1 (hFAS/iso:1) Interaction PR:P15311 (hEZR) PRO 14739941


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T40 I40 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T219 A219 Biomuta DOID:1324 / lung cancer [ tcga ]
T219 S219 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y232 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
K274 I274 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K300 E300 Biomuta DOID:1324 / lung cancer [ tcga ]
K309 Q309 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S320 I320 Biomuta DOID:363 / uterine cancer [ tcga ]