iPTMnet Report for P25445 (FAS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25445 / TNR6_HUMAN
Protein Name Tumor necrosis factor receptor superfamily member 6 precursor
Gene Name Name: FAS
Synonyms:APT1,FAS1,TNFRSF6;
Organism Homo sapiens (Human)

PRO ID PR:P25445
DAG View
PRO Name tumor necrosis factor receptor superfamily member 6 (human)
Definition A tumor necrosis factor receptor superfamily member 6 that is encoded in the genome of human.
Short Label hFAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25445 (FAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T28 O-Glycosylation GlyGen   UniProt 25813380, 22171320
K33 Ubiquitination PhosphoSitePlus
T40 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T42 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T43 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T46 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
Y91 Phosphorylation phospho.ELM   PhosphoSitePlus 17195092, 15660394
N118 N-Glycosylation GlyGen   UniProt 19159218, 24190977
N132 N-Glycosylation GlyGen 24190977
N136 N-Glycosylation GlyGen 24190977
K204 Ubiquitination PhosphoSitePlus
S209 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S212 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T214 O-Glycosylation GlyGen 30459171, 25813380
T214 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T219 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S225 Phosphorylation PhosphoSitePlus   UniProt 24275569
S230 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17195092, 15660394, 20682655
T234 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P 17195092, 15660394, 11786908, ...20682655
T293 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S209 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S212 Phosphorylation HPRD 18669648, 20068231
T214 Phosphorylation HPRD 18669648
T219 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K170 Acetylation PhosphoSitePlus
S188 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S191 Phosphorylation HPRD 18669648, 20068231
T193 Phosphorylation HPRD 18669648
T198 Phosphorylation HPRD 18669648


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036782 (hFASLG/iso:FasL/var:F273L) altered Interaction PR:P25445 (hFAS) PRO 9405425
PR:P25445-1 (hFAS/iso:1) Interaction PR:P15311 (hEZR) PRO 14739941


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T198 I198 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T198 A198 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]