Protein Information

Cytoscape View


UniProt AC / UniProt ID P25440 / BRD2_HUMAN
Protein Name Bromodomain-containing protein 2
Gene Name Name: BRD2
Synonyms:KIAA9001,RING3;
Organism Homo sapiens (Human)

PRO ID PR:P25440
DAG View
PRO Name bromodomain-containing protein 2 (human)
Definition A bromodomain-containing protein 2 that is encoded in the genome of human.
Short Label hBRD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25440 (BRD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 20068231
T6 Phosphorylation PhosphoSitePlus   UniProt 20068231
K10 Acetylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y40 Phosphorylation PhosphoSitePlus
S45 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T47 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S50 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T57 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K118 Ubiquitination PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
S208 O-Glycosylation GlyGen 32119511, 29351928
S211 O-Glycosylation GlyGen 32119511, 29351928
S219 O-Glycosylation GlyGen 32119511, 29351928
S220 O-Glycosylation GlyGen 32119511, 29351928
T235 O-Glycosylation GlyGen 32119511, 29351928
T236 O-Glycosylation GlyGen 32119511, 29351928
S248 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
T287 Phosphorylation phospho.ELM 18669648
T291 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 19690332, 20068231
S301 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 15302935, 18669648, ...24275569, 19690332, 20068231
S305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S320 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S334 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
R449 Methylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S611 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T613 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K614 Acetylation PhosphoSitePlus
K617 Acetylation PhosphoSitePlus
T629 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
S633 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S639 Phosphorylation phospho.ELM 18669648
S643 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
T690 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
Y715 Phosphorylation PhosphoSitePlus
T716 Phosphorylation PhosphoSitePlus
T724 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K725 Acetylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
K760 Acetylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
T795 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 20068231
S45 Phosphorylation HPRD 18669648, 20068231
T47 Phosphorylation HPRD 18669648
S50 Phosphorylation HPRD 18669648
T57 Phosphorylation HPRD 18669648
T287 Phosphorylation HPRD 18669648
T291 Phosphorylation HPRD 18669648
S298 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S301 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 20068231
S305 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S320 Phosphorylation HPRD 17287340
S340 Phosphorylation HPRD 20068231
S608 Phosphorylation HPRD 20068231
S611 Phosphorylation HPRD 18669648, 20068231
T613 Phosphorylation HPRD 18669648
S633 Phosphorylation HPRD 18669648, 20068231
S639 Phosphorylation HPRD 18669648
T724 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 Y37 Biomuta DOID:1909 / melanoma [ cosmic ]
S248 F248 Biomuta DOID:1909 / melanoma [ tcga ]
K400 R400 Biomuta DOID:3070 / malignant glioma [ tcga ]
K400 M400 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S639 N639 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T724 I724 Biomuta DOID:363 / uterine cancer [ tcga ]
S775 N775 Biomuta DOID:1115 / sarcoma [ tcga ]