Protein Information

Cytoscape View


UniProt AC / UniProt ID P25325 / THTM_HUMAN
Protein Name 3-mercaptopyruvate sulfurtransferase
Gene Name Name: MPST
Synonyms:TST2;
Organism Homo sapiens (Human)

PRO ID PR:P25325
DAG View
PRO Name 3-mercaptopyruvate sulfurtransferase (human)
Definition A 3-mercaptopyruvate sulfurtransferase that is encoded in the genome of human.
Short Label hMPST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25325 (MPST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 25944712
S3 Phosphorylation PhosphoSitePlus   UniProt 24275569
S12 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 24275569
K40 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
K170 Sumoylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 20068231
S35 Phosphorylation HPRD 20068231
S250 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 20166139, 18669648, 20230923
S17 Phosphorylation HPRD 20166139, 18669648, 20230923
S23 Phosphorylation HPRD 20068231
S55 Phosphorylation HPRD 20068231
S270 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K40 E40 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y272 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]