iPTMnet Report for P25205 (MCM3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25205 / MCM3_HUMAN
Protein Name DNA replication licensing factor MCM3
Gene Name Name: MCM3
Organism Homo sapiens (Human)

PRO ID PR:P25205
DAG View
PRO Name DNA replication licensing factor MCM3 (human)
Definition A DNA replication licensing factor MCM3 that is encoded in the genome of human.
Short Label hMCM3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25205 (MCM3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T4 Phosphorylation PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S112 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P 30316783, 18524952, 31186514
S112 Phosphorylation P06493 (CDK1) RLIMS-P+ 18524952
C126 Methylation IEDB 31844290
K140 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
C148 Methylation IEDB 31844290
C148 S-Nitrosylation dbSNO 19483679, 2212679, 22126794, ...26338901
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T154 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 30069701, 25367160, 34019948, 35083852, 22967762, 32119511, 28510447
T154 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
S160 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25809478, 21406692, 33936100, ...18669648, 18283219
S160 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 25809478
S160 Phosphorylation P53355 (DAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18283219
T163 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
R234 Methylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
K248 Sumoylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
C263 S-Nitrosylation dbSNO 26338901
K266 Sumoylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 23186163
K283 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
R371 Methylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
T384 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
R419 Methylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S535 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15210935
S535 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor 15210935
S535 Phosphorylation Q13535 (ATR) PhosphoSitePlus 15210935
Y545 Phosphorylation PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
K556 Acetylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
K559 Acetylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S611 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 23186163, 18524952
T617 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 30069701, 25367160, 34019948, 35083852, 22967762, 32119511, 28510447
T617 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
S668 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S672 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...21406692, 18669648, 19690332, 20068231, 16964243
T674 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...17525332, 18669648, 19690332, 17081983
S681 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648
K688 Ubiquitination PhosphoSitePlus
S704 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17287340
Y705 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y708 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 19690332
S711 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...18669648, 19690332, 20068231
T713 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 15302935, ...18669648, 19690332
T722 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21965652, 30316783, ...23186163, 17081983, 19369195, 15302935, 18524952, 18669648, 17487921, 19690332, 20068231
T722 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 21965652
T725 Phosphorylation PhosphoSitePlus   UniProt 19690332
S728 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 17244605, 17525332
S728 Phosphorylation Q13315 (ATM) neXtProt 17244605
K732 Sumoylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
S734 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K736 Sumoylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
R743 Methylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P25205 (MCM3) T722 Q13526 (PIN1) unknown eFIP 30316783


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K315 N315 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K315 T315 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]