iPTMnet Report for P25092 (GUCY2C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P25092 / GUC2C_HUMAN
Protein Name Guanylyl cyclase C precursor
Gene Name Name: GUCY2C
Synonyms:GUC2C,STAR;
Organism Homo sapiens (Human)

PRO ID PR:P25092
DAG View
PRO Name guanylyl cyclase C (human)
Definition A guanylyl cyclase C that is encoded in the genome of human.
Short Label hGUCY2C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P25092 (GUCY2C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N32 N-Glycosylation GlyGen   UniProt 23269669
N75 N-Glycosylation GlyGen   UniProt 23269669
N79 N-Glycosylation GlyGen   UniProt 23269669
T189 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
N195 N-Glycosylation GlyGen   UniProt 23269669
Y256 Phosphorylation PhosphoSitePlus
N284 N-Glycosylation GlyGen   UniProt 23269669
N307 N-Glycosylation GlyGen   UniProt 23269669
N345 N-Glycosylation GlyGen   UniProt 23269669
T396 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
N402 N-Glycosylation GlyGen   UniProt 23269669
T404 Phosphorylation PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K516 Acetylation PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
Y664 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
Y681 Phosphorylation PhosphoSitePlus
Y771 Phosphorylation PhosphoSitePlus
Y940 Phosphorylation PhosphoSitePlus
S965 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1001 Phosphorylation PhosphoSitePlus
S1052 Phosphorylation PhosphoSitePlus
K1054 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N79 K79 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y681 H681 Biomuta DOID:9256 / colorectal cancer [ cosmic ]