iPTMnet Report for P24928 (POLR2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P24928 / RPB1_HUMAN
Protein Name DNA-directed RNA polymerase II subunit RPB1
Gene Name Name: POLR2A
Synonyms:POLR2;
Organism Homo sapiens (Human)

PRO ID PR:P24928
DAG View
PRO Name DNA-directed RNA polymerase II subunit RPB1 (human)
Definition A DNA-directed RNA polymerase II subunit RPB1 that is encoded in the genome of human.
Short Label hPOLR2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24928 (POLR2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 19413330
S8 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus   UniProt 23186163
K32 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
Y145 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K149 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K213 Sumoylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus   UniProt 23186163
K226 Ubiquitination PhosphoSitePlus
C233 Methylation IEDB 31844290
S269 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
R426 Methylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
K707 Sumoylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
K708 Methylation PhosphoSitePlus
K710 Acetylation PhosphoSitePlus
K710 Sumoylation PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T732 Phosphorylation PhosphoSitePlus
T736 Phosphorylation HPRD   PhosphoSitePlus 18452278
K751 Ubiquitination PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
Y763 Phosphorylation PhosphoSitePlus
K767 Methylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K803 Methylation PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
K914 Ubiquitination PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus
K940 Ubiquitination PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
K1008 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
C1050 Methylation IEDB 31844290
K1125 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
K1155 Ubiquitination PhosphoSitePlus
C1159 Methylation IEDB 31844290
K1225 Sumoylation PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus
K1234 Ubiquitination PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
K1268 Ubiquitination PhosphoSitePlus   UniProt 32142649, 32142654
K1278 Ubiquitination PhosphoSitePlus
K1317 Ubiquitination PhosphoSitePlus
K1319 Ubiquitination PhosphoSitePlus
K1350 Ubiquitination PhosphoSitePlus
Y1383 Phosphorylation PhosphoSitePlus
T1406 Phosphorylation PhosphoSitePlus
T1415 Phosphorylation PhosphoSitePlus
T1424 Phosphorylation PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
S1534 O-Glycosylation GlyGen 22605332, 22371499, 34725712, ...26853435, 29351928, 34019948, 26807597
T1540 Phosphorylation PhosphoSitePlus
R1603 Methylation UniProt 26700805
Y1615 Phosphorylation PhosphoSitePlus
S1616 Phosphorylation Q14004 (CDK13) , Q9NYV4 (CDK12) , P78527 (PRKDC) , P50613 (CDK7) , Q13627 (DYRK1A) , O60885 (BRD4) , P50750 (CDK9) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 26748711, 22012619, 23249733, ...19575011, 25620562, 10958691, 9130709, 19450536, 17259211, 10886368, 20457598, 14662762, 24385927, 19901026, 19667075, 25561469, 32917631, 22053051, 20106982, 22509028, 14517250
T1618 O-Glycosylation PhosphoSitePlus
T1618 Phosphorylation P50750 (CDK9) neXtProt   PhosphoSitePlus 22053051
S1619 O-Glycosylation GlyGen 22605332, 22371499, 34725712, ...26853435, 29351928, 34019948, 26807597
S1619 Phosphorylation P27361 (MAPK3) , P50750 (CDK9) , Q13627 (DYRK1A) , P28482 (MAPK1) , P49336 (CDK8) , Q9NYV4 (CDK12) , Q14004 (CDK13) , P50613 (CDK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 26748711, 19667075, 20098423, ...17259211, 9130709, 25620562, 10886368, 12721286, 19450536, 24662513, 14662762, 14517250, 10958691, 19901026, 10364292, 22588304, 22117896, 25561469, 20106982
S1621 O-Glycosylation GlyGen 22605332, 22371499, 34725712, ...26853435, 29351928, 34019948, 26807597
S1621 Phosphorylation P78527 (PRKDC) , P50750 (CDK9) , P50613 (CDK7) neXtProt   PhosphoSitePlus 26748711, 10886368, 20457598, ...24662513, 19901026, 19667075, 9130709, 19450536, 25561469
S1623 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1626 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) Signor 14662762
S1644 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1647 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) Signor 14662762
S1651 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1654 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) Signor 14662762
S1665 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1668 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) Signor 14662762
S1672 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1675 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) Signor 14662762
S1693 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) Signor 24385927, 32917631
S1696 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) Signor 14662762
S1714 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) Signor 24385927, 32917631
S1717 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) Signor 14662762
S1721 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1724 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P50613 (CDK7) Signor 14662762
S1735 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) Signor 24385927, 32917631
S1738 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) Signor 14662762
S1763 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631
S1766 Phosphorylation P28482 (MAPK1) , P50613 (CDK7) , P27361 (MAPK3) Signor 14662762
S1784 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) Signor 24385927, 32917631
S1787 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) Signor 14662762
R1810 Methylation PhosphoSitePlus   UniProt 26700805, 21454787
Y1811 Phosphorylation PhosphoSitePlus
T1812 Phosphorylation PhosphoSitePlus
S1815 Phosphorylation PhosphoSitePlus
Y1818 Phosphorylation PhosphoSitePlus
T1819 Phosphorylation PhosphoSitePlus
S1821 Phosphorylation PhosphoSitePlus
S1822 O-Glycosylation GlyGen 27129214
S1822 Phosphorylation PhosphoSitePlus
S1824 Phosphorylation PhosphoSitePlus
Y1825 Phosphorylation PhosphoSitePlus
S1826 Phosphorylation PhosphoSitePlus
S1828 Phosphorylation PhosphoSitePlus
S1829 Phosphorylation PhosphoSitePlus
S1831 Phosphorylation PhosphoSitePlus
Y1832 Phosphorylation PhosphoSitePlus
S1833 Phosphorylation PhosphoSitePlus
S1836 Phosphorylation HPRD   PhosphoSitePlus 15302935
K1838 Acetylation PhosphoSitePlus
Y1839 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1840 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685
T1842 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1843 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18669648, 26566685, ...19690332
S1845 Phosphorylation PhosphoSitePlus   UniProt 26566685
Y1846 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1847 O-Glycosylation GlyGen 31373491
S1847 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
S1849 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 26566685, ...19664995
S1850 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 26566685, ...23186163
Y1853 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
T1854 Phosphorylation PhosphoSitePlus   UniProt 19690332
T1856 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1857 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685
K1859 Acetylation PhosphoSitePlus
K1859 Methylation UniProt 26566685
Y1860 Phosphorylation PhosphoSitePlus   UniProt 26566685
S1861 Phosphorylation Q9NYV4 (CDK12) , P50750 (CDK9) , Q14004 (CDK13) HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 32917631, 22012619, ...24385927, 26566685
T1863 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685
S1864 Phosphorylation P50613 (CDK7) , P28482 (MAPK1) , P27361 (MAPK3) HPRD   PhosphoSitePlus   Signor   UniProt 23186163, 14662762, 26566685, ...19413330
K1866 Acetylation PhosphoSitePlus   UniProt 26566685
K1866 Methylation UniProt 26566685
Y1867 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685
S1868 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) , Q9NYV4 (CDK12) HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 32917631, ...22012619, 24385927
T1870 Phosphorylation PhosphoSitePlus   UniProt 26566685
S1871 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P50613 (CDK7) HPRD   PhosphoSitePlus   Signor 19413330, 14662762
K1873 Methylation UniProt 26566685
Y1874 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19651622, 18669648, ...24275569, 26566685, 20068231
S1875 Phosphorylation P50750 (CDK9) , Q9NYV4 (CDK12) , Q14004 (CDK13) HPRD   PhosphoSitePlus   Signor   UniProt 32917631, 22012619, 19691289, ...19651622, 24385927, 26566685
T1877 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685, 19664995, ...20068231
S1878 Phosphorylation P50613 (CDK7) , P50750 (CDK9) , Q14004 (CDK13) , Q9NYV4 (CDK12) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 19413330, 23186163, 32917631, ...22012619, 27197304, 15570572, 19664995, 19651622, 18669648, 24385927, 26566685, 19690332, 20068231
T1880 Phosphorylation PhosphoSitePlus
Y1881 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 26566685
S1882 Phosphorylation Q14004 (CDK13) , P27361 (MAPK3) , Q9NYV4 (CDK12) , P24941 (CDK2) , P50613 (CDK7) , P28482 (MAPK1) , P50750 (CDK9) HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 32917631, ...22012619, 18847512, 15302935, 19691289, 19651622, 14662762, 24385927, 26566685, 19690332, 20068231
T1884 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 18847512, 19651622
T1885 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
K1887 Acetylation UniProt 26566685
K1887 Methylation UniProt 26566685
Y1888 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 19651622, 18669648
S1889 O-Glycosylation GlyGen 27129214
S1889 Phosphorylation Q14004 (CDK13) , Q9NYV4 (CDK12) , P50750 (CDK9) HPRD   PhosphoSitePlus   Signor 19413330, 24385927, 32917631, ...22012619
T1891 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
S1892 O-Glycosylation GlyGen 31373491
S1892 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P50613 (CDK7) HPRD   phospho.ELM   PhosphoSitePlus   Signor 19413330, 18669648, 14662762, ...20068231
T1894 O-Glycosylation GlyGen 31373491
T1894 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
Y1895 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1896 Phosphorylation Q9NYV4 (CDK12) , P50750 (CDK9) , Q14004 (CDK13) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 32917631, 22012619, ...15302935, 19651622, 18669648, 24385927
T1898 O-Glycosylation GlyGen 31373491
T1898 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
S1899 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P50613 (CDK7) HPRD   PhosphoSitePlus   Signor   UniProt 19413330, 23186163, 14662762, ...19690332, 20068231
Y1902 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1903 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
T1905 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 19664995, ...20068231
S1906 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 19651622, 19664995, ...24275569
Y1909 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 16964243, 18669648, ...24275569, 26566685
S1910 Phosphorylation P50750 (CDK9) , Q9NYV4 (CDK12) , Q14004 (CDK13) PhosphoSitePlus   Signor 24385927, 32917631, 22012619
T1912 Phosphorylation PhosphoSitePlus   UniProt 26566685
S1913 Phosphorylation P50613 (CDK7) , P27361 (MAPK3) , P28482 (MAPK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 14662762, 17322306, ...18669648, 26566685, 19690332
T1915 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 26566685, 18669648, 19664994, ...18847512
Y1916 Phosphorylation PhosphoSitePlus   UniProt 26566685
S1917 Phosphorylation P50750 (CDK9) , Q14004 (CDK13) , Q9NYV4 (CDK12) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 21406692, 32917631, ...22012619, 18847512, 18669648, 24385927, 26566685, 19690332
T1919 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 26566685
S1920 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P06493 (CDK1) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18234856, 14662762, ...18669648, 26566685, 19690332
K1922 Acetylation UniProt 26566685
K1922 Methylation UniProt 26566685
Y1923 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 26566685, 16964243, ...24275569
S1924 Phosphorylation Q14004 (CDK13) , Q9NYV4 (CDK12) , P50750 (CDK9) PhosphoSitePlus   Signor 24385927, 32917631, 22012619
T1926 Phosphorylation PhosphoSitePlus   UniProt 26566685
S1927 Phosphorylation P50613 (CDK7) , P28482 (MAPK1) , P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 14662762, 15144186, ...18669648, 26566685, 19690332
T1929 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 26566685, 15144186
Y1930 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 26566685, 15144186
S1931 Phosphorylation Q14004 (CDK13) , Q9NYV4 (CDK12) , P50750 (CDK9) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 32917631, 22012619, ...18669648, 24385927, 26566685, 19690332
T1933 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 26566685
S1934 Phosphorylation P27361 (MAPK3) , P06493 (CDK1) , P28482 (MAPK1) , P50613 (CDK7) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18234856, 15302935, ...14662762, 18669648, 19690332
K1936 Acetylation UniProt 26566685
K1936 Methylation UniProt 26566685
S1941 Phosphorylation Q14004 (CDK13) , P50750 (CDK9) , Q9NYV4 (CDK12) PhosphoSitePlus   Signor 24385927, 32917631, 22012619
S1944 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) Signor 14662762
S1948 Phosphorylation Q9NYV4 (CDK12) , Q14004 (CDK13) , P50750 (CDK9) Signor 24385927, 32917631, 22012619
S1951 Phosphorylation P27361 (MAPK3) , P50613 (CDK7) , P28482 (MAPK1) PhosphoSitePlus   Signor 14662762
S1962 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
S1966 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S1791 Phosphorylation PRO
S1794 Phosphorylation PRO
S1796 Phosphorylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048850 (hPOLR2A/PhosSer+) p PRO
PR:000048846 (hPOLR2A/Phos:1) pS1791,pS1794 PRO
PR:000048847 (hPOLR2A/Phos:2) pS1791,pS1796 PRO
PR:000048848 (hPOLR2A/Phos:3) pS1794 PRO
PR:000048849 (hPOLR2A/Phos:4) pS1794,pS1796 PRO