iPTMnet Report P24864 CCNE1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P24864 / CCNE1_HUMAN
Protein Name	G1/S-specific cyclin-E1
Gene Name	Name: CCNE1 Synonyms:CCNE;
Organism	Homo sapiens (Human)

PRO ID	PR:P24864 DAG View
PRO Name	G1/S-specific cyclin-E1 (human)
Definition	A G1/S-specific cyclin-E1 that is encoded in the genome of human.
Short Label	hCCNE1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P24864 (CCNE1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S59	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17525332
	S73	Phosphorylation	P49841 (GSK3B)	score2	PhosphoSitePlus	14536078
	T77	Phosphorylation	P49841 (GSK3B)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	14536078, 17434132, 15364936
	S90	Phosphorylation		score1	PhosphoSitePlus
	S103	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	18691976, 15364936, 23186163, ...19369195
	S366	Phosphorylation		score0	RLIMS-P	29760377
	S381	Phosphorylation		score1	PhosphoSitePlus
	S387	Phosphorylation	P24941 (CDK2)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	18691976, 23186163, 19369195, ...19561641, 15364936, 14536078, 18669648
	S391	Phosphorylation		score1	phospho.ELM	18669648
	T395	Phosphorylation	P49840 (GSK3A) , P49841 (GSK3B) , P24941 (CDK2)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	17434132, 19561641, 14536078, ...18691976, 8861947
	S399	Phosphorylation	P24941 (CDK2)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	14536078, 17218276, 17434132, ...22558078

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S59	Phosphorylation		score0	HPRD	17525332
	T77	Phosphorylation		score1	HPRD	14536078
	S100	Phosphorylation		score0	HPRD	18691976
	S103	Phosphorylation		score0	HPRD	18691976, 19664994
	S381	Phosphorylation		score0	HPRD	18691976
	S387	Phosphorylation		score2	HPRD	14536078, 18691976, 18669648
	S391	Phosphorylation		score0	HPRD	18691976, 18669648
	T395	Phosphorylation	P49841 (GSK3B)	score2	HPRD	14536078, 18691976, 8861947
	S399	Phosphorylation	P24941 (CDK2)	score2	HPRD	14536078, 18691976

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S384	Phosphorylation		score2	PRO	16223725

P24864 (CCNE1) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q8TDN4-2 (CABLES1)	S48	score2	HPRD	11733001, 18691976

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000025637 (hCCNE1/iso:3/Phos:1)	pS384		PRO	16223725

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P24864 (CCNE1)	S366	P24941 (CDK2)	inhibited_association	eFIP	29760377

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:000025637 (hCCNE1/iso:3/Phos:1)	Interaction	PR:Q13526 (hPIN1)	PRO	16223725
	PR:000025750 (hCDKN1B/iso:1/Phos:2)	Interaction	PR:P24864 (hCCNE1)	PRO	17254966

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S90	L90	Biomuta		DOID:363 / uterine cancer [ icgc ]
S381	C381	Biomuta		DOID:1324 / lung cancer [ cosmic ]
S384	I384	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S384	R384	Biomuta		DOID:1324 / lung cancer [ cosmic ]
S391	R391	Biomuta		DOID:1324 / lung cancer [ cosmic ]
T395	P395	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T395	I395	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S399	I399	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S399	R399	Biomuta		DOID:1324 / lung cancer [ cosmic ]