Protein Information

Cytoscape View


UniProt AC / UniProt ID P24844 / MYL9_HUMAN
Protein Name Myosin regulatory light polypeptide 9
Gene Name Name: MYL9
Synonyms:MLC2,MRLC1,MYRL2;
Organism Homo sapiens (Human)

PRO ID PR:P24844
DAG View
PRO Name myosin regulatory light polypeptide 9 (human)
Definition A myosin regulatory light polypeptide 9 that is encoded in the genome of human.
Short Label hMYL9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24844 (MYL9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   Signor 22136066, 12802051, 18835557
S2 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 22136066, 12802051, 18835557
S3 Phosphorylation PhosphoSitePlus   Signor 22136066, 12802051, 18835557
S3 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 22136066, 12802051, 18835557
T10 Phosphorylation PhosphoSitePlus   Signor 22136066, 12802051, 18835557
T10 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 22136066, 12802051, 18835557
T11 Phosphorylation PhosphoSitePlus
T19 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11942626, 21457715, 2526655, ...26169356, 12802051, 18854160, 18669648, 18835557, 19851336, 8702756, 15096528, 15723050
T19 Phosphorylation O14578 (CIT) PhosphoSitePlus 12802051, 18854160
T19 Phosphorylation O43293 (DAPK3) phospho.ELM   Signor 15096528, 19851336
T19 Phosphorylation O75116 (ROCK2) Signor 8702756
T19 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus 26169356
T19 Phosphorylation Q15746 (MYLK) PhosphoSitePlus   Signor 19851336, 18835557
T19 Phosphorylation Q5VT25 (CDC42BPA) Signor 19851336
S20 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 11942626, 10047984, 21457715, ...2526655, 20956536, 10356987, 26169356, 21072057, 18854160, 12802051, 12081505, 18669648, 17015463, 19851336, 8702756, 10947843, 18835557, 15723050, 3839510, 21408167
S20 Phosphorylation O14578 (CIT) PhosphoSitePlus 12802051
S20 Phosphorylation O43293 (DAPK3) phospho.ELM   Signor 10356987, 19851336
S20 Phosphorylation O75116 (ROCK2) neXtProt   Signor 17015463, 8702756
S20 Phosphorylation Q13153 (PAK1) PhosphoSitePlus 18854160
S20 Phosphorylation Q13177 (PAK2) phospho.ELM 10047984
S20 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor 26169356, 12802051, 8702756
S20 Phosphorylation Q14012 (CAMK1) neXtProt   PhosphoSitePlus 12081505
S20 Phosphorylation Q15746 (MYLK) PhosphoSitePlus   Signor 19851336, 18835557, 3839510
S20 Phosphorylation Q5VT25 (CDC42BPA) neXtProt   PhosphoSitePlus   Signor 19851336, 18854160, 21457715
S20 Phosphorylation Q9Y5S2 (CDC42BPB) neXtProt 10947843, 21457715
S29 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T128 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation phospho.ELM   PhosphoSitePlus 8578591
Y143 Phosphorylation P00533 (EGFR) phospho.ELM 8578591
K150 Ubiquitination PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation phospho.ELM   PhosphoSitePlus 8578591
Y156 Phosphorylation P00533 (EGFR) phospho.ELM 8578591
K164 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation HPRD 19562805, 20166139, 18669648, ...19664995, 20068231
S20 Phosphorylation HPRD 20166139, 18669648, 18491316, ...20068231, 18707149
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation HPRD 19562805, 20166139, 18669648, ...19664995, 20068231
S20 Phosphorylation HPRD 20166139, 18669648, 18491316, ...20068231, 18707149


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048505 (hMYL9/InitMet-/Phos:1) pS20 PRO
PR:000048506 (hMYL9/InitMet-/Phos:2) pT19 PRO
PR:000048507 (hMYL9/InitMet-/Phos:3) pT19,pS20 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P24844 (MYL9) S20 unknown eFIP 20956536


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T11 I11 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ tcga ]
T11 S11 Biomuta DOID:363 / uterine cancer [ tcga ]
S60 L60 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K168 * Biomuta DOID:1909 / melanoma [ tcga ]