iPTMnet Report for P24752 (ACAT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P24752 / THIL_HUMAN
Protein Name Acetyl-CoA acetyltransferase, mitochondrial precursor
Gene Name Name: ACAT1
Synonyms:ACAT,MAT;
Organism Homo sapiens (Human)

PRO ID PR:P24752
DAG View
PRO Name acetyl-CoA acetyltransferase, mitochondrial (human)
Definition An acetyl-CoA acetyltransferase, mitochondrial that is encoded in the genome of human.
Short Label hACAT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24752 (ACAT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 O-Glycosylation GlyGen 28510447, 33465208
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus   UniProt 19608861
K174 Ubiquitination PhosphoSitePlus
K181 Acetylation PhosphoSitePlus   UniProt 19608861
K181 Ubiquitination PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K202 Acetylation PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus   UniProt 19608861
K257 Acetylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
K263 Ubiquitination PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation P36888 (FLT3) , P11362 (FGFR1) PhosphoSitePlus   Signor 27867011, 34289383
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S128 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 I10 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S16 G16 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y90 C90 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S116 Y116 Biomuta DOID:363 / uterine cancer [ icgc ]
K203 R203 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T285 S285 Biomuta DOID:10283 / prostate cancer [ icgc ]
K302 N302 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y407 C407 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]