Protein Information

Cytoscape View

UniProt AC / UniProt ID P24723 / KPCL_HUMAN
Protein Name Protein kinase C eta type
Gene Name Name: PRKCH
Organism Homo sapiens (Human)

PRO ID PR:P24723
DAG View
PRO Name protein kinase C eta type (human)
Definition A protein kinase C eta type that is encoded in the genome of human.
Short Label hPRKCH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P24723 (PRKCH) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation PhosphoSitePlus
S28 Phosphorylation P24723 (PRKCH) PhosphoSitePlus   UniProt 16973127, 23186163
S32 Phosphorylation P24723 (PRKCH) PhosphoSitePlus   UniProt 16973127
K36 Ubiquitination PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
S642 Phosphorylation RLIMS-P 30154443
T656 Phosphorylation PhosphoSitePlus   UniProt 24275569
S675 Phosphorylation PhosphoSitePlus
Y676 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S317 Phosphorylation HPRD 19413330
S320 Phosphorylation HPRD 19413330
T656 Phosphorylation HPRD 20058876

P24723 (PRKCH) as PTM Enzyme

Substrate Site Score Source PMID
P04083 (ANXA1) S27 Signor 24103589
P05107 (ITGB2) S745 PhosphoSitePlus   Signor 11700305
P05107 (ITGB2) T758 PhosphoSitePlus   Signor 11700305
P09211 (GSTP1) S43 PhosphoSitePlus 15604283
P09211 (GSTP1) S185 PhosphoSitePlus 15604283
P24723 (PRKCH) S28 PhosphoSitePlus   UniProt 16973127
P24723 (PRKCH) S32 PhosphoSitePlus   UniProt 16973127
P29474 (NOS3) T495 Signor 24379783
P49840 (GSK3A) S21 PhosphoSitePlus   Signor 11884598
P49841 (GSK3B) S9 PhosphoSitePlus   Signor 11884598, 19836308
Q04206 (RELA) S536 neXtProt 21820409
Q06124-2 (PTPN11) S576 HPRD   Signor 11781100
Q15139 (PRKD1) S738 HPRD   neXtProt   PhosphoSitePlus   Signor 11741879, 10197446, 10867018
Q15139 (PRKD1) S742 neXtProt   PhosphoSitePlus   Signor 11741879, 10197446
Q16625 (OCLN) T403 neXtProt 19114660
Q16625 (OCLN) T404 neXtProt 19114660
Q9BZL6 (PRKD2) S706 neXtProt   PhosphoSitePlus   Signor 12058027
Q9BZL6 (PRKD2) S710 neXtProt   PhosphoSitePlus   Signor 12058027
Q9BZL6 (PRKD2) S876 neXtProt   PhosphoSitePlus   Signor 12058027

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S317 F317 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S317 Y317 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
S320 L320 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
S326 L326 Biomuta DOID:363 / uterine cancer [ tcga ]
K384 N384 Biomuta DOID:3571 / liver cancer [ icgc ]
S465 L465 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K591 N591 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K591 E591 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K615 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]