iPTMnet Report for P24394 (IL4R)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P24394 / IL4RA_HUMAN
Protein Name Interleukin-4 receptor subunit alpha precursor
Gene Name Name: IL4R
Synonyms:IL4RA;ORFNames:582J2.1;
Organism Homo sapiens (Human)

PRO ID PR:P24394
DAG View
PRO Name interleukin-4 receptor subunit alpha (human)
Definition An interleukin-4 receptor subunit alpha that is encoded in the genome of human.
Short Label hIL4R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24394 (IL4R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N53 N-Glycosylation GlyGen 24190977
N176 N-Glycosylation GlyGen 29671580, 24190977
K192 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
T476 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8124718, 9545332, 9697832
Y575 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 8624803, 9392697, 10358772
Y603 Phosphorylation IntAct   phospho.ELM   UniProt 8624803, 9392697, 10358772, ...9712048
S616 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation IntAct   phospho.ELM   UniProt 8624803, 8816495, 9651359, ...10358772
Y713 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 9670964, 11714803
S753 Phosphorylation PhosphoSitePlus
T756 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
Y821 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N176 N-Glycosylation PRO 29671580
Y497 Phosphorylation HPRD 9545332, 9697832
Y575 Phosphorylation HPRD 8624803
Y603 Phosphorylation HPRD 8624803
Y631 Phosphorylation HPRD 8624803
Y713 Phosphorylation HPRD 9670964


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N176 S176 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S387 L387 Biomuta DOID:4159 / skin cancer [ cosmic ]
T487 M487 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y603 C603 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y713 H713 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S753 L753 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y821 C821 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]