iPTMnet Report for P24385 (CCND1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P24385 / CCND1_HUMAN
Protein Name G1/S-specific cyclin-D1
Gene Name Name: CCND1
Synonyms:BCL1;
Organism Homo sapiens (Human)

PRO ID PR:P24385
DAG View
PRO Name G1/S-specific cyclin-D1 (human)
Definition A G1/S-specific cyclin-D1 that is encoded in the genome of human.
Short Label hCCND1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P24385 (CCND1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K33 Ubiquitination PhosphoSitePlus
K46 Methylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S90 Phosphorylation P17612 (PRKACA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 8058338
K95 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S97 Phosphorylation IEDB 35494241
S111 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
C189 Methylation IEDB 31844290
S197 Phosphorylation P17612 (PRKACA) HPRD   phospho.ELM   PhosphoSitePlus 8058338
S219 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
S234 Phosphorylation P17612 (PRKACA) HPRD   phospho.ELM   PhosphoSitePlus 8058338
K238 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus   UniProt 33854235
T286 Phosphorylation Q13627 (DYRK1A) , Q9Y463 (DYRK1B) , P49841 (GSK3B) , O15111 (CHUK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10766840, 20394812, 15735756, ...26157550, 17081987, 29328502, 19412162, 18063576, 28870200, 27670681, 28035994, 23733133, 22069692, 21411630, 19374252, 17046823, 33854232, 32944401, 19071090, 18818515, 25142862, 29298515, 27424123, 26121043, 10952989, 20655656, 19903334, 16732330, 29969496, 15513923, 23552696, 17205132, 18838555, 26926171, 23949314, 19767775, 24119401, 10910956, 33139730, 18328826, 24275569, 16504004, 32700164, 31484966, 30224477, 22266466, 27713153, 14612495, 25603341, 23162706, 33854239, 18769147, 21347341, 21241249, 25615593, 18606783, 24134204, 17359980, 29039762, 31262325, 33046973, 16153639, 24280698, 25479723, 30736789, 9832503, 29442024, 16942622, 33854235, 16103118, 33521925, 27854312, 11751903, 29554905, 30157875
T288 Phosphorylation Q9Y463 (DYRK1B) , P49841 (GSK3B) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 22711815, 24280698, 15075324, ...17046823, 24134204


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027132 (hCCND1/Phos:1) pT286 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P24385 (CCND1) T286 Q8N3Y1 (FBXW8) unknown eFIP 17205132
Phosphorylation P24385 (CCND1) T286 Q5XUX0 (FBXO31) unknown eFIP 19412162


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24385 (hCCND1) PRO 17254966
PR:000027132 (hCCND1/Phos:1) increased Interaction PR:000037513 (FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)) PRO 17407548