Protein Information

Cytoscape View


UniProt AC / UniProt ID P23921 / RIR1_HUMAN
Protein Name Ribonucleoside-diphosphate reductase large subunit
Gene Name Name: RRM1
Synonyms:RR1;
Organism Homo sapiens (Human)

PRO ID PR:P23921
DAG View
PRO Name ribonucleoside-diphosphate reductase large subunit (human)
Definition A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of human.
Short Label hRRM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23921 (RRM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K17 Acetylation PhosphoSitePlus   UniProt 19608861
K17 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
R80 Methylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S253 O-Glycosylation GlyGen 30853214, 16408927, 28510447
S253 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
K320 Methylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K376 Acetylation PhosphoSitePlus   UniProt 19608861
K376 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T422 Phosphorylation HPRD   PhosphoSitePlus 20068231
K424 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K465 Acetylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K496 Acetylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   RLIMS-P 32712628
K563 Ubiquitination PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
S606 O-Glycosylation GlyGen 30853214, 16408927, 28510447
S631 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K681 Ubiquitination PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
T734 O-Glycosylation GlyGen 30853214, 16408927, 28510447
Y738 Phosphorylation PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus   UniProt 23186163
K754 Ubiquitination PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
S764 O-Glycosylation GlyGen 30853214, 16408927, 28510447
K765 Ubiquitination PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K180 N180 Biomuta DOID:363 / uterine cancer [ tcga ]
K414 N414 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y485 S485 Biomuta DOID:1612 / breast cancer [ tcga ]
K681 N681 Biomuta DOID:363 / uterine cancer [ tcga ]
S764 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]