Protein Information

Cytoscape View

UniProt AC / UniProt ID P23919 / KTHY_HUMAN
Protein Name Thymidylate kinase
Gene Name Name: DTYMK
Organism Homo sapiens (Human)

PRO ID PR:P23919
DAG View
PRO Name thymidylate kinase (human)
Definition A thymidylate kinase that is encoded in the genome of human.
Short Label hDTYMK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P23919 (DTYMK) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K25 Acetylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
C31 S-Nitrosylation dbSNO 19483679, 22178444
R41 Methylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
R143 Methylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus   UniProt 19608861
K176 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
R192 Methylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K212 Acetylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T92 I92 Biomuta DOID:1324 / lung cancer [ cosmic ]
R143 W143 Biomuta DOID:363 / uterine cancer [ tcga ]
R192 H192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R192 S192 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T201 A201 Biomuta DOID:1115 / sarcoma [ tcga ]
K212 E212 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]