iPTMnet Report for P23804 (Mdm2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23804 / MDM2_MOUSE
Protein Name E3 ubiquitin-protein ligase Mdm2
Gene Name Name: Mdm2
Organism Mus musculus (Mouse)

PRO ID PR:P23804
DAG View
PRO Name E3 ubiquitin-protein ligase Mdm2 (mouse)
Definition An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of mouse.
Short Label mMDM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23804 (Mdm2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation RLIMS-P 21303257, 24504419
S17 Phosphorylation RLIMS-P 25543083
K51 Acetylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation Q8BSK8 (Rps6kb1) , P31750 (Akt1) , P42337 (Pik3ca) PhosphoSitePlus   RLIMS-P 31557161, 20657550, 25526089
T165 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33468664, 21183079
S185 Phosphorylation PhosphoSitePlus
T216 Phosphorylation P97377 (Cdk2) phospho.ELM   PhosphoSitePlus   RLIMS-P 11359766
S238 Phosphorylation phospho.ELM   PhosphoSitePlus 15610030
S240 Phosphorylation Q9WV60 (Gsk3b) phospho.ELM   PhosphoSitePlus 16055726, 15610030
S244 Phosphorylation phospho.ELM   PhosphoSitePlus 16055726, 15610030
S254 Phosphorylation Q9WV60 (Gsk3b) phospho.ELM   PhosphoSitePlus 16055726
S258 Phosphorylation IntAct   PhosphoSitePlus 19833129
Y274 Phosphorylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
Y393 Phosphorylation P00520 (Abl1) RLIMS-P+ 27956626
S394 Phosphorylation Q62388 (Atm) PhosphoSitePlus   RLIMS-P+   RLIMS-P 22624716, 28892044, 27568562, ...27956626


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S15 P23804 (Mdm2) inhibited_association eFIP 30337688
Phosphorylation P23804 (Mdm2) T216 unknown eFIP 11359766
Phosphorylation P23804 (Mdm2) S17 P04637 (TP53) inhibited_association eFIP 32477121